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Ppp1r35 protein phosphatase 1, regulatory subunit 35 [ Mus musculus (house mouse) ]

Gene ID: 69871, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp1r35provided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 35provided by MGI
Primary source
MGI:MGI:1922853
See related
Ensembl:ENSMUSG00000029725 AllianceGenome:MGI:1922853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010007H12Rik; 2010011D20Rik
Summary
Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Involved in notochord morphogenesis and positive regulation of cilium assembly. Predicted to be located in centrosome. Predicted to be active in centriole. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and hemolymphoid system. Orthologous to human PPP1R35 (protein phosphatase 1 regulatory subunit 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.8), thymus adult (RPKM 25.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r35 in Genome Data Viewer
Location:
5 G2; 5 76.7 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137777138..137778372)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137778904..137780110)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Tsc22 domain family, member 4 Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator Neighboring gene STARR-positive B cell enhancer ABC_E4797 Neighboring gene STARR-positive B cell enhancer ABC_E857 Neighboring gene STARR-positive B cell enhancer ABC_E1312 Neighboring gene STARR-positive B cell enhancer ABC_E4798 Neighboring gene methylphosphate capping enzyme Neighboring gene zinc finger, CW type with PWWP domain 1 Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Archambault D, et al. Dev Biol, 2020 Sep 1. PMID 32628936, Free PMC Article
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
    Title: Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of centriole elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centriole elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 35
Names
UPF0683 protein C7orf47 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356989.1 → NP_001343918.1  protein phosphatase 1 regulatory subunit 35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC125063
    Conserved Domains (1) summary
    pfam15503
    Location:107 → 158
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

  2. NM_027242.5 → NP_081518.1  protein phosphatase 1 regulatory subunit 35 isoform 1

    See identical proteins and their annotated locations for NP_081518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125063, AK008148
    Consensus CDS
    CCDS19777.1
    UniProtKB/Swiss-Prot
    Q9D8C8
    Related
    ENSMUSP00000031739.5, ENSMUST00000031739.6
    Conserved Domains (1) summary
    pfam15503
    Location:107 → 253
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137777138..137778372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254798.2 → XP_030110658.1  protein phosphatase 1 regulatory subunit 35 isoform X1

    Conserved Domains (1) summary
    pfam15503
    Location:107 → 207
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8C8.1 GenPept UniProtKB/Swiss-Prot:Q9D8C8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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