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Pla2g12b phospholipase A2, group XIIB [ Mus musculus (house mouse) ]

Gene ID: 69836, updated on 28-Oct-2024

Summary

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Official Symbol
Pla2g12bprovided by MGI
Official Full Name
phospholipase A2, group XIIBprovided by MGI
Primary source
MGI:MGI:1917086
See related
Ensembl:ENSMUSG00000009646 AllianceGenome:MGI:1917086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fksg71; hlb218; Pla2g13; 2010002E04Rik
Summary
Predicted to enable calcium ion binding activity and phospholipase A2 activity. Acts upstream of or within cholesterol homeostasis; low-density lipoprotein particle remodeling; and triglyceride homeostasis. Predicted to be located in extracellular region. Is expressed in alimentary system; liver; liver lobe; and yolk sac endoderm. Orthologous to human PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in placenta adult (RPKM 23.7), large intestine adult (RPKM 22.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Pla2g12b in Genome Data Viewer
Location:
10 B4; 10 29.54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59239242..59257798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59403420..59421976)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26769 Neighboring gene procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene oncoprotein induced transcript 3 Neighboring gene predicted gene, 36318 Neighboring gene mitochondrial calcium uniporter Neighboring gene STARR-seq mESC enhancer starr_26771 Neighboring gene STARR-seq mESC enhancer starr_26772 Neighboring gene predicted gene, 40671

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of the NF-κB Pathway to Promote Membrane Nephropathy. Fu L, et al. Kidney Blood Press Res, 2023. PMID 37757774
  2. Pla2g12b drives expansion of triglyceride-rich lipoproteins. Thierer JH, et al. Nat Commun, 2024 Mar 7. PMID 38453914, Free PMC Article
  3. Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B. Chen L, et al. FASEB J, 2019 Jul. PMID 30922124
  4. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A₂ GXIIB. Guan M, et al. Hepatology, 2011 Feb. PMID 21274867
  5. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Rouault M, et al. Biochemistry, 2003 Oct 7. PMID 14516201

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pla2g12b drives expansion of triglyceride-rich lipoproteins.
    Title: Pla2g12b drives expansion of triglyceride-rich lipoproteins.
  2. PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of the NF-kappaB Pathway to Promote Membrane Nephropathy.
    Title: PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of the NF-κB Pathway to Promote Membrane Nephropathy.
  3. ERRgamma transcriptionally regulates the expression of PLA2G12B by binding to its promoter region. In Pla2g12b-null mice, ERRgamma fails to regulate hepatic VLDL-TG secretion and lipid droplets accumulate in the liver. ERRgamma is a novel regulator of hepatic VLDL-TG secretion, which is mediated through the action on PLA2G12B.
    Title: Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B.
  4. FXR regulates serum triglyceride level in part through PLA2G12B.
    Title: Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression.
  5. Low HDL Cholesterol Levels in strain Hlb218 Is Caused by a Mutation at amino acid position 129 in the third exon of Pla2g12b.
    Title: Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
group XIIB secretory phospholipase A2-like protein
Names
GXIIB
group XIIB phospholipase A2
group XIII secretory phospholipase A2-like protein
phospholipase A2, group XIII
sPLA2-GXIIB
NP_076019.2
XP_006514124.1
XP_006514125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023530.2 → NP_076019.2  group XIIB secretory phospholipase A2-like protein precursor

    See identical proteins and their annotated locations for NP_076019.2

    Status: VALIDATED

    Source sequence(s)
    BC021592
    Consensus CDS
    CCDS23864.1
    UniProtKB/Swiss-Prot
    Q99P27
    UniProtKB/TrEMBL
    Q8VC81
    Related
    ENSMUSP00000009790.8, ENSMUST00000009790.14
    Conserved Domains (1) summary
    pfam06951
    Location:18 → 195
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    59239242..59257798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514062.4 → XP_006514125.1  group XIIB secretory phospholipase A2-like protein isoform X2

    Conserved Domains (1) summary
    cl29745
    Location:68 → 210
    Phospholip_A2_3; Prokaryotic phospholipase A2

  2. XM_006514061.3 → XP_006514124.1  group XIIB secretory phospholipase A2-like protein isoform X1

    Conserved Domains (1) summary
    pfam06951
    Location:68 → 244
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P27.1 GenPept UniProtKB/Swiss-Prot:Q99P27

Gene LinkOut

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