Zswim7 zinc finger SWIM-type containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zswim7provided by MGI
Official Full Name: zinc finger SWIM-type containing 7provided by MGI
Primary source: MGI:MGI:1916997
See related: Ensembl:ENSMUSG00000014243 AllianceGenome:MGI:1916997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SWS1; 2410012H22Rik
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in double-strand break repair via homologous recombination and protein stabilization. Predicted to be located in nucleus. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure 71. Orthologous to human ZSWIM7 (zinc finger SWIM-type containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 30.3), kidney adult (RPKM 11.1) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 B2; 11 37.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (62158050..62172221, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (62267224..62281395, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Title: Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
These results demonstrate an essential role for SWS1-SWSAP1 in meiotic progression and emphasize the complex interplay of factors that ensure recombinase function.
Title: Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1)

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:488807

NoName (e-PCR)
- UniSTS:487912

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Shu complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Shu complex	IEA Inferred from Electronic Annotation more info
part_of Shu complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: zinc finger SWIM domain-containing protein 7

Names: SWIM domain-containing and Srs2-interacting protein 1 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.