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Wdr20 WD repeat domain 20 [ Mus musculus (house mouse) ]

Gene ID: 69641, updated on 2-Nov-2024

Summary

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Official Symbol
Wdr20provided by MGI
Official Full Name
WD repeat domain 20provided by MGI
Primary source
MGI:MGI:1916891
See related
Ensembl:ENSMUSG00000037957 AllianceGenome:MGI:1916891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr20a; 2310040A13Rik
Summary
Predicted to enable deubiquitinase activator activity. Predicted to be located in cytoplasm and nucleus. Orthologous to human WDR20 (WD repeat domain 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.4), thymus adult (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wdr20 in Genome Data Viewer
Location:
12 F1; 12 60.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110701459..110770709)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110735025..110804275)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53768 Neighboring gene STARR-positive B cell enhancer mm9_chr12:111934512-111934812 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111945270-111945457 Neighboring gene STARR-seq mESC enhancer starr_33300 Neighboring gene STARR-seq mESC enhancer starr_33301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111976119-111976302 Neighboring gene STARR-seq mESC enhancer starr_33302 Neighboring gene STARR-positive B cell enhancer ABC_E5355 Neighboring gene MOK protein kinase Neighboring gene STARR-seq mESC enhancer starr_33307 Neighboring gene RIKEN cDNA 4921507G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E5356 Neighboring gene STARR-positive B cell enhancer ABC_E1865 Neighboring gene STARR-positive B cell enhancer ABC_E4044 Neighboring gene nuclear encoded tRNA isoleucine 6 (anticodon AAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Yu C, et al. Science, 2013 Dec 20. PMID 24357321
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deubiquitinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 20
Names
WD repeat domain 20A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347428.2 → NP_001334357.1  WD repeat-containing protein 20 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK009711, BP753580
    Consensus CDS
    CCDS84002.1
    UniProtKB/TrEMBL
    A0A0A6YX87, Q9D721
    Related
    ENSMUSP00000141678.2, ENSMUST00000193053.6

  2. NM_001364272.1 → NP_001351201.1  WD repeat-containing protein 20 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596265
    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:113 → 178
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:109 → 274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001364273.1 → NP_001351202.1  WD repeat-containing protein 20 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596265
    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:12 → 77
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:8 → 173
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_027149.4 → NP_081425.2  WD repeat-containing protein 20 isoform 1

    See identical proteins and their annotated locations for NP_081425.2

    Status: VALIDATED

    Source sequence(s)
    AI303487, AK136417, BC064773
    Consensus CDS
    CCDS26173.1
    UniProtKB/TrEMBL
    Q3ULP2, Q3UWE6
    Related
    ENSMUSP00000093059.3, ENSMUST00000095410.8
    Conserved Domains (3) summary
    COG2319
    Location:147 → 389
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:153 → 218
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149 → 314
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110701459..110770709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516203.4 → XP_006516266.1  WD repeat-containing protein 20 isoform X1

    UniProtKB/TrEMBL
    Q3ULP2
    Conserved Domains (2) summary
    sd00039
    Location:153 → 218
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:149 → 314
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006516204.4 → XP_006516267.1  WD repeat-containing protein 20 isoform X2

    UniProtKB/TrEMBL
    Q3ULP2
    Conserved Domains (2) summary
    sd00039
    Location:153 → 218
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:149 → 314
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036157607.1 → XP_036013500.1  WD repeat-containing protein 20 isoform X7

    UniProtKB/TrEMBL
    A0A0A6YX87

  4. XM_036157606.1 → XP_036013499.1  WD repeat-containing protein 20 isoform X7

    UniProtKB/TrEMBL
    A0A0A6YX87

  5. XM_006516205.4 → XP_006516268.1  WD repeat-containing protein 20 isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:113 → 178
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:109 → 274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_036157605.1 → XP_036013498.1  WD repeat-containing protein 20 isoform X4

    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:113 → 178
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:109 → 274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_030246901.1 → XP_030102761.1  WD repeat-containing protein 20 isoform X6

    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:50 → 86
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:47 → 146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_011244170.4 → XP_011242472.1  WD repeat-containing protein 20 isoform X5

    See identical proteins and their annotated locations for XP_011242472.1

    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:12 → 77
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:8 → 173
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_006516207.5 → XP_006516270.1  WD repeat-containing protein 20 isoform X6

    UniProtKB/TrEMBL
    A0A1Y7VJI5
    Conserved Domains (2) summary
    sd00039
    Location:50 → 86
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:47 → 146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004937540.1 RNA Sequence

  2. XR_872718.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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