TRD T cell receptor delta locus [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRDprovided by HGNC
Official Full Name: T cell receptor delta locusprovided by HGNC
Primary source: HGNC:HGNC:12252
See related: AllianceGenome:HGNC:12252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCRD; TRD@; TCRDV1
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Genomic context

Location:: 14q11.2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (22422546..22466577)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (16620292..16664335)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (22891537..22935569)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Memory and naive gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.
Title: Memory and naïve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.
This study investigated the proportion, phenotype and T cell receptor gamma and delta repertoires of gamma delata T cells at the maternalfetal interface and in the blood of pregnant women. The study found an enrichment of activated and terminally differentiated pro-inflammatory gamma delta T-cell effectors with specific location in the human decidua during early pregnancy.
Title: Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires.
Studies indicate that gamma/delta T cells (gammadelta T cells) can be 'developmentally programmed' in the thymus to generate discrete gammadelta T cell effector subsets with distinctive molecular signatures.
Title: Thymic Determinants of γδ T Cell Differentiation.
Vgamma9Vdelta2 TCR activation is modulated by the GTPase activity of RhoB and its redistribution to BTN3A1.
Title: RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.
Studies indicate that gammadelta TCR (gammadelta) T-cells play an essential role in the recruitment of inflammatory cells and pro-inflammatory cytokines to the injury site after burn.
Title: The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury.
The nanobodies (VHHs) are useful for flow cytometry, magnetic-activated cell sorting and immunocytochemistry to study Vgamma9Vdelta2-T cells.
Title: Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.
Data indicate the expression of a chimeric T-cell receptor alpha beta (alphabeta TCR) harboring the immunoglobulin-like (Ig) domain of T-cell receptor gamma delta (gammadelta TCR) in Jurkat T cells.
Title: [Homology modeling and eukaryotic expression of a modified αβ TCR harboring the immunoglobulin-like domain of γδ TCR].
Studies indicate that T-cell receptors Tcra and Tcrd transit from an unrearranged configuration to a rearranged configuration during T-cell development.
Title: Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.
Gamma-delta T cells and their corresponding T cell receptors hold pomise for cancer immunotherapy. (Review)
Title: The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.
The delta2-chain complementarity determining region 3 (delta2 CDR3) the gammadelta T-cell receptor of pulmonary tuberculosis patients apparently drifts, and the predominant delta2 CDR3 sequence that recognizes Mycobacterium tuberculosis may exhibit specificity.
Title: Characteristics of the Vδ2 CDR3 Sequence of Peripheral γδ T Cells in Patients with Pulmonary Tuberculosis and Identification of a New Tuberculosis-Related Antigen Peptide.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

G35434 (e-PCR)
- UniSTS:44199

SHGC-171779 (e-PCR)
- UniSTS:185292

D14S920 (e-PCR)
- UniSTS:4328

GDB:210884 (e-PCR)
- UniSTS:156157

D14S1186 (e-PCR)
- UniSTS:39678

Other Names

T-cell antigen receptor, delta polypeptide
T-cell receptor, delta (V,D,J,C)
TCRD, TRD@

Clone Names

FLJ52034, FLJ52576, FLJ53668, FLJ54555, FLJ55265, FLJ56790

General protein information

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Names: T cell receptor delta locus; T-cell antigen receptor, delta polypeptide; T-cell receptor, delta (V,D,J,C); TCRD, TRD@

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.