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Nup35 nucleoporin 35 [ Mus musculus (house mouse) ]

Gene ID: 69482, updated on 2-Nov-2024

Summary

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Official Symbol
Nup35provided by MGI
Official Full Name
nucleoporin 35provided by MGI
Primary source
MGI:MGI:1916732
See related
Ensembl:ENSMUSG00000026999 AllianceGenome:MGI:1916732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MP44; NO44; 35kDa; 2310006I24Rik; 5330402E05Rik
Summary
Enables identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus and plasma membrane. Predicted to be part of nuclear pore central transport channel and nuclear pore nuclear basket. Is expressed in cerebellum. Used to study intestinal pseudo-obstruction. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 15.4), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nup35 in Genome Data Viewer
Location:
2 C3; 2 48.31 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (80469156..80490415)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (80638812..80660071)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13688 Neighboring gene STARR-positive B cell enhancer ABC_E7830 Neighboring gene STARR-seq mESC enhancer starr_04952 Neighboring gene dual specificity phosphatase 19 Neighboring gene microRNA 684-1 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene predicted gene, 36282 Neighboring gene predicted gene, 25420 Neighboring gene STARR-seq mESC enhancer starr_04953 Neighboring gene STARR-seq mESC enhancer starr_04955 Neighboring gene putative Eno1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleoporin35 is a novel microtubule associated protein functioning in oocyte meiotic spindle architecture. Chen F, et al. Exp Cell Res, 2018 Oct 15. PMID 30195030
  2. A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy. Parish IA, et al. Am J Pathol, 2016 Sep. PMID 27427419, Free PMC Article
  3. The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain. Handa N, et al. J Mol Biol, 2006 Oct 13. PMID 16962612
  4. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Xiao J, et al. Exp Neurol, 2016 Sep. PMID 27163549, Free PMC Article
  5. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that Nup35 is putatively phosphorylated and released to the cytoplasm after resumption of meiosis, and it regulates spindle assembly and chromosome alignment.
    Title: Nucleoporin35 is a novel microtubule associated protein functioning in oocyte meiotic spindle architecture.
  2. Our study also raises the possibility that Nup35 polymorphisms could contribute to some cases of Chronic intestinal pseudo-obstruction
    Title: A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy.
  3. The crystal structure of the Nup35 RNA-recognition motif (RRM) domain has been solved; the Nup35 RRM domain monomer adopts the characteristic betaalphabetabetaalphabeta topology revealing a new homodimerization mode.
    Title: The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 
  • Targeted (2) 
  • Transgenic (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear pore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear lamina ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore nuclear basket IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleoporin NUP35
Names
35 kDa nucleoporin
mitotic phosphoprotein 44
nuclear pore complex protein Nup53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190179.1 → NP_001177108.1  nucleoporin NUP35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR/coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK136109, AK145775, CA560987, DV653588
    UniProtKB/Swiss-Prot
    Q8R4R6
    Conserved Domains (1) summary
    cd12722
    Location:154 → 227
    RRM_Nup53; RNA recognition motif in nucleoporin Nup53

  2. NM_027091.4 → NP_081367.1  nucleoporin NUP35 isoform 1

    See identical proteins and their annotated locations for NP_081367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK136109, AK145775, BY272877
    Consensus CDS
    CCDS16179.1
    UniProtKB/Swiss-Prot
    A2ATJ3, Q8R4R6, Q9D7J2
    Related
    ENSMUSP00000028382.7, ENSMUST00000028382.13
    Conserved Domains (1) summary
    cd12722
    Location:171 → 244
    RRM_Nup53; RNA recognition motif in nucleoporin Nup53

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    80469156..80490415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4R6.2 GenPept UniProtKB/Swiss-Prot:Q8R4R6

Gene LinkOut

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