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Commd10 COMM domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 69456, updated on 26-Jun-2024

Summary

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Official Symbol
Commd10provided by MGI
Official Full Name
COMM domain containing 10provided by MGI
Primary source
MGI:MGI:1916706
See related
Ensembl:ENSMUSG00000042705 AllianceGenome:MGI:1916706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRWMS2; VavCre; Vav-cre; Vav-iCre; Vav1-Cre; 2310003A05Rik; Tg(Vav1-icre)A2Kio
Summary
Predicted to be located in nucleoplasm. Orthologous to human COMMD10 (COMM domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 9.6), CNS E11.5 (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Commd10 in Genome Data Viewer
Location:
18 C; 18 24.9 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (47091917..47242435)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46958819..47087995)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3744 Neighboring gene STARR-positive B cell enhancer ABC_E5655 Neighboring gene predicted gene, 49974 Neighboring gene predicted gene, 22791 Neighboring gene STARR-positive B cell enhancer mm9_chr18:47157285-47157586 Neighboring gene STARR-seq mESC enhancer starr_44533 Neighboring gene heat shock protein 1 (chaperonin 10), related sequence 1 Neighboring gene ADP-ribosylation factor interacting protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. COMMD10 Is Essential for Neural Plate Development during Embryogenesis. Phan KP, et al. J Dev Biol, 2023 Mar 16. PMID 36976102, Free PMC Article
  2. Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. Joseph C, et al. Cell Stem Cell, 2013 Nov 7. PMID 24209759
  3. Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Ogilvy S, et al. Blood, 1999 Sep 15. PMID 10477714
  4. Tyk2 is a tumor suppressor in colorectal cancer. Moritsch S, et al. Oncoimmunology, 2022. PMID 36185806, Free PMC Article
  5. Chromatin organizer SATB1 controls the cell identity of CD4(+) CD8(+) double-positive thymocytes by regulating the activity of super-enhancers. Feng D, et al. Nat Commun, 2022 Sep 22. PMID 36138028, Free PMC Article

See all (519) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERAdP-mediated production of pro-inflammatory cytokines is critical for controlling bacterial infection
    Title: The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity.
  2. COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
    Title: COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
  3. COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver.
    Title: COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver.
  4. Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.
    Title: Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.
  5. these results highlight COMMD10 as a negative regulator of Ly6Chi monocyte inflammasome activity during systemic inflammation
    Title: Impaired COMMD10-Mediated Regulation of Ly6C(hi) Monocyte-Driven Inflammation Disrupts Gut Barrier Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COMM domain-containing protein 10
Names
Tg(Vav1-cre)1Kio
Tg(Vav1-cre)A2Kio
down-regulated in W/WV mouse stomach 2
mDRWMS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418791.1 → NP_001405720.1  COMM domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  2. NM_001418792.1 → NP_001405721.1  COMM domain-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  3. NM_001418808.1 → NP_001405737.1  COMM domain-containing protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100
    UniProtKB/TrEMBL
    A0A3Q4EHW7, Q3UTM6
    Related
    ENSMUSP00000157148.2, ENSMUST00000234961.2

  4. NM_001418809.1 → NP_001405738.1  COMM domain-containing protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132100
    UniProtKB/TrEMBL
    Q3UTM6
    Related
    ENSMUSP00000157292.2, ENSMUST00000234124.2

  5. NM_001418810.1 → NP_001405739.1  COMM domain-containing protein 10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100
    UniProtKB/TrEMBL
    A0A3Q4EC50
    Related
    ENSMUSP00000157272.2, ENSMUST00000234701.2

  6. NM_001418811.1 → NP_001405740.1  COMM domain-containing protein 10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  7. NM_001418812.1 → NP_001405741.1  COMM domain-containing protein 10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  8. NM_001418813.1 → NP_001405742.1  COMM domain-containing protein 10 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100
    UniProtKB/TrEMBL
    A0A3Q4EII3
    Related
    ENSMUSP00000157358.2, ENSMUST00000234280.2

  9. NM_001418814.1 → NP_001405743.1  COMM domain-containing protein 10 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  10. NM_001418815.1 → NP_001405744.1  COMM domain-containing protein 10 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100
    UniProtKB/TrEMBL
    A0A3Q4EGT0
    Related
    ENSMUSP00000157146.2, ENSMUST00000234085.2

  11. NM_001418816.1 → NP_001405745.1  COMM domain-containing protein 10 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  12. NM_001418817.1 → NP_001405746.1  COMM domain-containing protein 10 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

  13. NM_178377.5 → NP_848464.1  COMM domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_848464.1

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100
    Consensus CDS
    CCDS29238.1
    UniProtKB/Swiss-Prot
    Q8JZY2
    UniProtKB/TrEMBL
    Q3TKN7, Q3UTM6
    Related
    ENSMUSP00000041650.8, ENSMUST00000049388.9
    Conserved Domains (1) summary
    cd04758
    Location:15 → 201
    Commd10; COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RNA

  1. NR_184828.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117239, AC132100

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    47091917..47242435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZY2.1 GenPept UniProtKB/Swiss-Prot:Q8JZY2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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