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NCOA2 nuclear receptor coactivator 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 693455, updated on 17-Aug-2024

Summary

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Official Symbol
NCOA2provided by VGNC
Official Full Name
nuclear receptor coactivator 2provided by VGNC
Primary source
VGNC:VGNC:75146
See related
Ensembl:ENSMMUG00000015978
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NCOA2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
27
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (70707484..71004061, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (68291271..68640472, complement)

Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene PR/SET domain 14 Neighboring gene transcription factor BTF3 pseudogene Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene translocation associated membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041761.1 Reference Mmul_10 Primary Assembly

    Range
    70707484..71004061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015145551.2 → XP_015001037.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/TrEMBL
    A0A5F8AQQ8, G7MZI4
    Related
    ENSMMUP00000080285.1, ENSMMUT00000109124.1
    Conserved Domains (10) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    cd00130
    Location:123 → 213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08430
    Location:1240 → 1358
    Forkhead_N; Forkhead N-terminal region
    pfam00989
    Location:119 → 215
    PAS; PAS fold
    pfam07469
    Location:1212 → 1269
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1047
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  2. XM_001082161.4 → XP_001082161.2  nuclear receptor coactivator 2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5QKI2, G7MZI4, H9ET70
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1281 → 1338
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:892 → 1372
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  3. XM_028852733.1 → XP_028708566.1  nuclear receptor coactivator 2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5QKI2, G7MZI4, H9ET70
    Related
    ENSMMUP00000048555.2, ENSMMUT00000053746.2
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1281 → 1338
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:892 → 1372
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  4. XM_028852728.1 → XP_028708561.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    G7MZI4
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1351 → 1407
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1135 → 1484
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  5. XM_028852734.1 → XP_028708567.1  nuclear receptor coactivator 2 isoform X3

    UniProtKB/TrEMBL
    G7MZI4
    Related
    ENSMMUP00000064603.1, ENSMMUT00000087488.1
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1282 → 1338
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1002 → 1047
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1066 → 1415
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  6. XM_028852729.1 → XP_028708562.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    G7MZI4
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1351 → 1407
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1135 → 1484
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  7. XM_028852730.1 → XP_028708563.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    G7MZI4
    Related
    ENSMMUP00000071891.1, ENSMMUT00000104457.1
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1351 → 1407
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1135 → 1484
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  8. XM_028852731.1 → XP_028708564.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    G7MZI4
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1351 → 1407
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1135 → 1484
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  9. XM_028852732.1 → XP_028708565.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    G7MZI4
    Conserved Domains (9) summary
    smart00353
    Location:35 → 88
    HLH; helix loop helix domain
    smart00091
    Location:118 → 175
    PAS; PAS domain
    pfam07469
    Location:1351 → 1407
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1071 → 1116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640 → 709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1135 → 1484
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268 → 378
    PAS_11; PAS domain
    pfam16279
    Location:731 → 816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463 → 587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
Nucleotide Protein
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