GNLY granulysin [Gallus gallus (chicken)] - Gene

Summary

Symbol: GNLYprovided by CGNC
Full Name: granulysinprovided by CGNC
Primary source: CGNC:54353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	22	NC_052553.1 (4551575..4552746, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	22	NC_052594.1 (4597031..4598213, complement)

Chromosome 22 - NC_052553.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix.
Title: Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix.
Chicken NK-lysin inhibits the growth of a representative gram-negative bacterium, Escherichia coli. The antimicrobial activity of 2 peptides designated H23 and H34 was similar to that of mature NK-lysin, cNK-78.
Title: Chicken NK-lysin is an alpha-helical cationic peptide that exerts its antibacterial activity through damage of bacterial cell membranes.
A difference in electrostatic interaction between lipid membranes and helical peptides results from the polymorphic gene and is subsequently an important factor in cell lytic activity of variant NK-lysin peptides.
Title: Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells.
molecular cloning; chicken NK-lysin plays important roles during anti-microbial and anti-tumor defenses [NK-lysin]
Title: Molecular cloning and characterization of chicken NK-lysin.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytolytic granule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: granulysin

Names: NK-lysin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044680.2 → NP_001038145.2 granulysin precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000335

UniProtKB/TrEMBL

Q2I811

Conserved Domains (1) summary

smart00741
Location:64 → 138

SapB; Saposin (B) Domains

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4551575..4552746 complement

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GenBank, FASTA, Sequence Viewer (Graphics)