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GPC1 glypican 1 [ Meleagris gallopavo (turkey) ]

Gene ID: 693243, updated on 5-Mar-2024

Summary

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Gene symbol
GPC1
Gene description
glypican 1
See related
Ensembl:ENSMGAG00000000842
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Meleagris gallopavo
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Meleagridinae; Meleagris
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See GPC1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
8
Annotation release Status Assembly Chr Location
103 current Turkey_5.1 (GCF_000146605.3) 11 NC_015021.2 (594823..674264)
Build 1.1 previous assembly Turkey_2.01 (GCF_000146605.1) 11 NC_015021.1 (630097..710702)

Chromosome 11 - NC_015021.2Genomic Context describing neighboring genes Neighboring gene glypican-5-like Neighboring gene uncharacterized LOC104912516 Neighboring gene uncharacterized LOC109369403 Neighboring gene dual specificity phosphatase 28 Neighboring gene dual specificity phosphatase 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data demonstrate that the satellite cell response to nutrition is dependent on the expression of syndecan-4 and glypican-1 in an age-dependent manner with growth selection having little impact.
    Title: The effect of nutrient restriction and syndecan-4 or glypican-1 knockdown on the differentiation of turkey pectoralis major satellite cells differing in age and growth selection.
  2. Dynamic changes in syndecan-4- and glypican-1-positive satellite cells indicate that they are differentially expressed during myogenesis.
    Title: Growth and sex effects on the expression of syndecan-4 and glypican-1 in turkey myogenic satellite cell populations.
  3. Glypican-1 regulates myogenic differentiation when it is shed into the extracellular matrix.
    Title: Modulation of turkey myogenic satellite cell differentiation through the shedding of glypican-1.
  4. These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 and syndecan-4 during satellite cell proliferation and differentiation, and Pax7 expression is influenced by glypican-1.
    Title: Heparan sulfate proteoglycans, syndecan-4 and glypican-1, differentially regulate myogenic regulatory transcription factors and paired box 7 expression during turkey satellite cell myogenesis: implications for muscle growth.
  5. These data suggest that glypican-1 N-glycosylated chains and GAG chains are critical in regulating turkey myogenic satellite cell proliferation, differentiation, and responsivness to FGF2.
    Title: Effect of glypican-1 covalently attached chains on turkey myogenic satellite cell proliferation, differentiation, and fibroblast growth factor 2 responsiveness.
  6. syndecan-1, syndecan-4, or glypican-1 differentially affect the processes of turkey muscle cell proliferation and differentiation, and can regulate these developmental stages in an FGF2-independent manner
    Title: Effect of syndecan-1, syndecan-4, and glypican-1 on turkey muscle satellite cell proliferation, differentiation, and responsiveness to fibroblast growth factor 2.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glypican-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303227.1 → NP_001290156.1  glypican-1 precursor

    See identical proteins and their annotated locations for NP_001290156.1

    Status: PROVISIONAL

    Source sequence(s)
    AY551002
    UniProtKB/TrEMBL
    G1MQ88, Q6QA54
    Related
    ENSMGAP00000000231.2, ENSMGAT00000000865.2
    Conserved Domains (1) summary
    pfam01153
    Location:10 → 541
    Glypican; Glypican

RefSeqs of Annotated Genomes: Meleagris gallopavo Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Turkey_5.1 Primary Assembly

Genomic

  1. NC_015021.2 Reference Turkey_5.1 Primary Assembly

    Range
    594823..674264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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