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TCF7 transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 6932, updated on 11-Apr-2024

Summary

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Official Symbol
TCF7provided by HGNC
Official Full Name
transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:11639
See related
Ensembl:ENSG00000081059 MIM:189908; AllianceGenome:HGNC:11639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCF-1
Summary
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
Expression
Broad expression in lymph node (RPKM 9.2), appendix (RPKM 6.3) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q31.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (134108218..134148210)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (134630059..134671840)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133450372..133483901)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23112 Neighboring gene MPRA-validated peak5471 silencer Neighboring gene voltage dependent anion channel 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133382518-133383158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133383159-133383798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133385203-133385778 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:133387505-133388080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133394172-133394770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133394771-133395367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23121 Neighboring gene short transmembrane mitochondrial protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422388-133422888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422889-133423389 Neighboring gene Sharpr-MPRA regulatory region 10905 Neighboring gene Sharpr-MPRA regulatory region 12956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133437181-133438148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133438510-133439380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133441120-133441988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133442973-133443520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133457701-133458202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133464814-133465636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133465637-133466458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133475053-133476030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16356 Neighboring gene S-phase kinase associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133513545-133514059 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23139 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133561503-133562022 Neighboring gene microRNA 3661

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p. Jiang Z, et al. J Diabetes Investig, 2023 Feb. PMID 36583231, Free PMC Article
  2. Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction. Zangari B, et al. Cancer Immunol Immunother, 2022 Dec. PMID 35460379, Free PMC Article
  3. TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/β‑catenin/TCF7/ABC transporter signaling axis. Zhang H, et al. Oncol Rep, 2021 Feb. PMID 33416164, Free PMC Article
  4. TCF7-L2 rs7903146 polymorphism in metabolic syndrome with and without acute coronary syndrome. Zafar U, et al. J Pak Med Assoc, 2020 Oct. PMID 33159751
  5. Clinical Significance of Transcription Factor 7 (TCF7) as a Prognostic Factor in Gastric Cancer. Xu X, et al. Med Sci Monit, 2019 May 28. PMID 31133633, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
    Title: Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T-cell function.
  2. TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
    Title: TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma.
  3. Characterization of TCF-1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients.
    Title: Characterization of TCF-1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients.
  4. Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis.
    Title: Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis.
  5. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.
    Title: Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.
  6. LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p.
    Title: LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p.
  7. Pancreatic stellate cells exploit Wnt/beta-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.
    Title: Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth.
  8. Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction.
    Title: Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction.
  9. Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.
    Title: Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.
  10. TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/betacatenin/TCF7/ABC transporter signaling axis.
    Title: TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/β‑catenin/TCF7/ABC transporter signaling axis.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36364, MGC47735

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-delta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of gamma-delta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor 7
Names
T-cell-factor-7
T-cell-specific transcription factor 1
transcription factor 7 (T-cell specific, HMG-box)

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030367.2 RefSeqGene

    Range
    11465..44994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134851.4 → NP_001128323.2  transcription factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001128323.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as A), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011336, HY048657, X59869, X59871
    Consensus CDS
    CCDS47263.2
    UniProtKB/TrEMBL
    E5RG34
    Related
    ENSP00000430179.1, ENST00000518915.5
    Conserved Domains (2) summary
    cd01388
    Location:154 → 224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 97
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. NM_001346425.2 → NP_001333354.1  transcription factor 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate exon in the coding region, compared to variant 1. The resulting isoform (5) is longer, compared to isoform 1.
    Source sequence(s)
    AC008608, AC011336, AK057580, AL832816, BC048769, CR976030, X59870
    UniProtKB/Swiss-Prot
    P36402
    UniProtKB/TrEMBL
    B3KQ75

  3. NM_001346450.2 → NP_001333379.1  transcription factor 7 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011336, CN274309, DB128524, X59871
    UniProtKB/TrEMBL
    E5RG34
    Related
    ENSP00000427870.2, ENST00000522375.6

  4. NM_001366502.2 → NP_001353431.1  transcription factor 7 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011336, AK310591, DB137814
    Conserved Domains (2) summary
    cd01388
    Location:129 → 199
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:12 → 72
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. NM_003202.5 → NP_003193.2  transcription factor 7 isoform 1

    See identical proteins and their annotated locations for NP_003193.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC008608, AC011336, AK057580, AL832816, BC048769, X59870
    Consensus CDS
    CCDS4169.1
    UniProtKB/Swiss-Prot
    P36402
    UniProtKB/TrEMBL
    B3KQ75
    Related
    ENSP00000340347.5, ENST00000342854.10
    Conserved Domains (2) summary
    cd01388
    Location:269 → 339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. NM_201632.5 → NP_963963.1  transcription factor 7 isoform 2

    See identical proteins and their annotated locations for NP_963963.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as B), differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC011336, AK057580, BC048769, DB106996, X59870
    Consensus CDS
    CCDS4170.1
    UniProtKB/TrEMBL
    E5RG34
    Related
    ENSP00000378469.1, ENST00000395023.5
    Conserved Domains (2) summary
    cd01388
    Location:154 → 224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 97
    CTNNB1_binding; N-terminal CTNNB1 binding

  7. NM_201634.5 → NP_963965.1  transcription factor 7 isoform 4

    See identical proteins and their annotated locations for NP_963965.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as C), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011336, CN274309, HY048657, X59871
    Consensus CDS
    CCDS43362.1
    UniProtKB/TrEMBL
    E5RG34
    Related
    ENSP00000367822.4, ENST00000378560.8
    Conserved Domains (2) summary
    cd01388
    Location:154 → 224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 97
    CTNNB1_binding; N-terminal CTNNB1 binding

  8. NM_213648.5 → NP_998813.1  transcription factor 7 isoform 2

    See identical proteins and their annotated locations for NP_998813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC011336, AK057580, AL832816, BC048769, DB137814, DB161143, X59870
    Consensus CDS
    CCDS4170.1
    UniProtKB/TrEMBL
    E5RG34
    Related
    ENSP00000429547.1, ENST00000520958.5
    Conserved Domains (2) summary
    cd01388
    Location:154 → 224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 97
    CTNNB1_binding; N-terminal CTNNB1 binding

RNA

  1. NR_033449.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' exon structure and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008608, AC011336, AK057580

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    134108218..134148210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417636.1 → XP_047273592.1  transcription factor 7 isoform X9

  2. XM_047417640.1 → XP_047273596.1  transcription factor 7 isoform X13

  3. XM_047417634.1 → XP_047273590.1  transcription factor 7 isoform X5

  4. XM_047417635.1 → XP_047273591.1  transcription factor 7 isoform X6

  5. XM_047417641.1 → XP_047273597.1  transcription factor 7 isoform X15

  6. XM_047417638.1 → XP_047273594.1  transcription factor 7 isoform X11

  7. XM_006714678.4 → XP_006714741.1  transcription factor 7 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:300 → 370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  8. XM_047417633.1 → XP_047273589.1  transcription factor 7 isoform X4

  9. XM_011543606.2 → XP_011541908.1  transcription factor 7 isoform X7

    Conserved Domains (2) summary
    cd01388
    Location:300 → 370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  10. XM_006714682.3 → XP_006714745.1  transcription factor 7 isoform X8

    Conserved Domains (2) summary
    cd01388
    Location:300 → 370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  11. XM_006714679.4 → XP_006714742.1  transcription factor 7 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:269 → 339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  12. XM_047417637.1 → XP_047273593.1  transcription factor 7 isoform X10

  13. XM_047417639.1 → XP_047273595.1  transcription factor 7 isoform X12

  14. XM_006714684.3 → XP_006714747.1  transcription factor 7 isoform X14

    UniProtKB/Swiss-Prot
    P36402
    Conserved Domains (2) summary
    cd01388
    Location:269 → 339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  15. XM_011543604.3 → XP_011541906.1  transcription factor 7 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:300 → 370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20 → 212
    CTNNB1_binding; N-terminal CTNNB1 binding

  16. XM_047417643.1 → XP_047273599.1  transcription factor 7 isoform X18

  17. XM_047417642.1 → XP_047273598.1  transcription factor 7 isoform X18

  18. XM_006714685.5 → XP_006714748.1  transcription factor 7 isoform X16

    Conserved Domains (2) summary
    cd01388
    Location:185 → 255
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 97
    CTNNB1_binding; N-terminal CTNNB1 binding

  19. XM_006714686.5 → XP_006714749.1  transcription factor 7 isoform X17

    Conserved Domains (2) summary
    cd01388
    Location:154 → 224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 97
    CTNNB1_binding; N-terminal CTNNB1 binding

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    134630059..134671840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353323.1 → XP_054209298.1  transcription factor 7 isoform X9

  2. XM_054353327.1 → XP_054209302.1  transcription factor 7 isoform X13

  3. XM_054353319.1 → XP_054209294.1  transcription factor 7 isoform X5

  4. XM_054353320.1 → XP_054209295.1  transcription factor 7 isoform X6

  5. XM_054353329.1 → XP_054209304.1  transcription factor 7 isoform X15

  6. XM_054353325.1 → XP_054209300.1  transcription factor 7 isoform X11

  7. XM_054353315.1 → XP_054209290.1  transcription factor 7 isoform X1

  8. XM_054353318.1 → XP_054209293.1  transcription factor 7 isoform X4

  9. XM_054353321.1 → XP_054209296.1  transcription factor 7 isoform X7

  10. XM_054353322.1 → XP_054209297.1  transcription factor 7 isoform X8

  11. XM_054353316.1 → XP_054209291.1  transcription factor 7 isoform X2

  12. XM_054353324.1 → XP_054209299.1  transcription factor 7 isoform X10

  13. XM_054353326.1 → XP_054209301.1  transcription factor 7 isoform X12

  14. XM_054353328.1 → XP_054209303.1  transcription factor 7 isoform X14

  15. XM_054353317.1 → XP_054209292.1  transcription factor 7 isoform X3

  16. XM_054353335.1 → XP_054209310.1  transcription factor 7 isoform X18

  17. XM_054353334.1 → XP_054209309.1  transcription factor 7 isoform X18

  18. XM_054353336.1 → XP_054209311.1  transcription factor 7 isoform X20

    UniProtKB/TrEMBL
    B3KQ75

  19. XM_054353330.1 → XP_054209305.1  transcription factor 7 isoform X16

  20. XM_054353331.1 → XP_054209306.1  transcription factor 7 isoform X17

  21. XM_054353332.1 → XP_054209307.1  transcription factor 7 isoform X19

  22. XM_054353333.1 → XP_054209308.1  transcription factor 7 isoform X19

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134852.1: Suppressed sequence

    Description
    NM_001134852.1: This RefSeq was temporarily suppressed because the CDS may possibly be 5'-partial, and the nature of its 5' end is unclear.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36402.3 GenPept UniProtKB/Swiss-Prot:P36402

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