MIR603 microRNA 603 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR603provided by HGNC
Official Full Name: microRNA 603provided by HGNC
Primary source: HGNC:HGNC:32859
See related: Ensembl:ENSG00000207930 miRBase:MI0003616; AllianceGenome:HGNC:32859
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN603; hsa-mir-603
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 10p12.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (24275685..24275781)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (24294224..24294320)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (24564614..24564710)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
Title: miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
MicroRNA-603 Promotes Progression of Cutaneous Melanoma by Regulating TBX5.
Title: MicroRNA-603 Promotes Progression of Cutaneous Melanoma by Regulating TBX5.
Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas.
Title: Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas.
miR-603 is a tumor suppressor targeting HK2 in ovarian cancer and its low level may result from DNMT3A-mediated methylation.
Title: miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells.
Reduction in BRCC2 expression induced by miR-603 was responsible for the enhanced colony formation and proliferative ability noted in the MG-63 and U2OS cells.
Title: MicroRNA-603 functions as an oncogene by suppressing BRCC2 protein translation in osteosarcoma.
This work suggests that miR-603 may be a novel Alzheimer's disease-relevant miRNA and that its rs11014002 single nucleotide polymorphism may serve as a protective factor
Title: Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease.
Mir603 rs11014002 T allele might contribute to the decreased risk of breast cancer in a sample of Iranian population.
Title: Association study of hsa-mir-603 rs11014002 polymorphism and risk of breast cancer in a sample of Iranian population.
The SNP rs6218 in IGF-1 3'-UTR, through disrupting the regulatory role of miR-603 in IGF-1 expression, might act as a gastric cancer tumorigenic factor.
Title: The Functional Variant in the 3'UTR of IGF1 with the Risk of Gastric Cancer in a Chinese Population.
miR-603 regulates glioma development via Wnt-beta-cateninn signaling pathway and its WIF1 and CTNNBIP1 targets.
Title: miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1.
High miR-603 is associated with laryngeal squamous cell carcinoma.
Title: Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma.

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Phenotypes

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Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.