MIR577 microRNA 577 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR577provided by HGNC
Official Full Name: microRNA 577provided by HGNC
Primary source: HGNC:HGNC:32833
See related: Ensembl:ENSG00000207931 miRBase:MI0003584; AllianceGenome:HGNC:32833
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN577; mir-577; hsa-mir-577
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 4q26

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (114656759..114656854)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (117960075..117960170)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (115577915..115578010)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-beta signaling pathway.
Title: MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-β signaling pathway.
Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression.
Title: Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression.
LncRNA DSCAM-AS1 promotes non-small cell lung cancer progression via regulating miR-577/HMGB1 axis.
Title: LncRNA DSCAM-AS1 promotes non-small cell lung cancer progression via regulating miR-577/HMGB1 axis.
Low miR577 expression is associated with invasion in nasopharyngeal carcinoma.
Title: Circular RNA circ_0008450 upregulates CXCL9 expression by targeting miR-577 to regulate cell proliferation and invasion in nasopharyngeal carcinoma.
these results indicated that miR577 may have served tumor suppressive roles in nonsmall cell lung cancer by directly targeting HOXA1
Title: microRNA‑577 inhibits cell proliferation and invasion in non‑small cell lung cancer by directly targeting homeobox A1.
DANCR promoted HSP27 expression and its mediation of proliferation/metastasis via miR-577 sponging.
Title: Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging.
Results indicated that miR-577 suppressed EMT by inhibiting Rab25 expression in breast cancer (BC). MiR-577 and Rab25 are considered potential targets of BC treatment.
Title: MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25.
MiR-577 serves an important role in regulating cell proliferation, migration and invasion, and the epithelial-mesenchymal transition process in non-small cell lung cancer cells and miR-577 may have inhibited WNT2B expression at both the mRNA and protein expression levels by directly targeting the 3'UTR of the WNT2B mRNA.
Title: miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer.
Study confirmed that miR577 expression was markedly downregulated in both in hepatocellular carcinoma (HCC) tissues and cell lines and related to malignant clinicopathological features, such as venous invasion and advanced TNM stage. MiR577 was identified as an inhibitor of cell metastatic ability and EMT progress in HCC through direct interaction with HOXA1.
Title: MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1.
the study revealed that lncRNA DANCR might promote the proliferation of osteoarthritis chondrocytes and reduce apoptosis through the miR-577/SphK2 axis.
Title: Long non-protein coding RNA DANCR functions as a competing endogenous RNA to regulate osteoarthritis progression via miR-577/SphK2 axis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.