MIR572 microRNA 572 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR572provided by HGNC
Official Full Name: microRNA 572provided by HGNC
Primary source: HGNC:HGNC:32828
See related: Ensembl:ENSG00000207716 miRBase:MI0003579; AllianceGenome:HGNC:32828
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN572; hsa-mir-572
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 4p15.33

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (11368827..11368921)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (11344886..11344980)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (11370451..11370545)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-572 promotes the development of non-small cell lung cancer by targeting KLF2.
Title: MiR-572 promotes the development of non-small cell lung cancer by targeting KLF2.
MicroRNA-572 targets CDH1 to promote metastasis of Wilms' tumor.
Title: MicroRNA-572 targets CDH1 to promote metastasis of Wilms' tumor.
Our results demonstrated that circADAMTS14 might suppress hepatocellular carcinoma (HCC) progression through regulating miR-572/ RCAN1 as the competing endogenous RNA.
Title: The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1.
Study suggests that tumor oncogene miR572 is a potential biomarker for the diagnosis, treatment and prognosis for renal cell carcinoma.
Title: microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis.
MIRN572 was found to regulate NCAM1 expression in an oligodendroglial cell line.
Title: NCAM1 is the Target of miRNA-572: Validation in the Human Oligodendroglial Cell Line.
The upregulation of miR-572 and miR-663a was consistent in both the SH-SY5Y and SK-N-SH cells.
Title: Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines.
miR-572 post-transcriptionally regulates SOCS1 and p21 and may play an important role in ovarian cancer progression; miR-572 may represent a potential therapeutic target for ovarian cancer therapy.
Title: Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression.
MicroRNA-572 is expressed differently in multiple sclerosis patients with different patterns of clinical progression
Title: MicroRNA-572 expression in multiple sclerosis patients with different patterns of clinical progression.
miR-572 is involved in the development and restoration of POCD and it may serve as a biological marker for early diagnosis of POCD.
Title: MicroRNA-572 improves early post-operative cognitive dysfunction by down-regulating neural cell adhesion molecule 1.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.