MIR550A1 microRNA 550a-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR550A1provided by HGNC
Official Full Name: microRNA 550a-1provided by HGNC
Primary source: HGNC:HGNC:32804
See related: Ensembl:ENSG00000207771 miRBase:MI0003600; AllianceGenome:HGNC:32804
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIR550-1; MIRN550-1; mir-550a-1; hsa-mir-550a-1
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 7p14.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (30289794..30289890)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (30427487..30427583)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (30329410..30329506)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway.
Title: miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway.
LINC00261/microRNA-550a-3p/SDPR axis affects the biological characteristics of breast cancer stem cells.
Title: LINC00261/microRNA-550a-3p/SDPR axis affects the biological characteristics of breast cancer stem cells.
Novel MicroRNA Biomarkers, miR-142-5p, miR-550a, miR-1826, and miR-1201, Were Identified for Primary Melanoma.
Title: Novel MicroRNA Biomarkers, miR-142-5p, miR-550a, miR-1826, and miR-1201, Were Identified for Primary Melanoma.
Bone-related circulating miRNAs miR-29b-3p, miR-550a-3p and miR-324-3p are significantly associated to dynamic processes of bone, reflected by bone histomorphometry. . miRNAs miR-29b-3p, miR-550a-3p and miR-324-3p were recently found to discriminate patients with low-traumatic fractures and are therefore promising new biomarkers for osteoporosis diagnosis
Title: Bone-related Circulating MicroRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry.
The novel connection between miR-550a-3p and ERK defines a new diagnostic and prognostic role for miR-550a-3p in breast cancer
Title: Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2.
miR-550a mediates the TNF-alpha-induced suppression of cyp27b1 expression in peripheral B cells of patients with diabetes, which can be blocked by inhibition of miR-550a.
Title: Micro RNA-550a interferes with vitamin D metabolism in peripheral B cells of patients with diabetes.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.