Pxt1 peroxisomal, testis specific 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pxt1provided by MGI
Official Full Name: peroxisomal, testis specific 1provided by MGI
Primary source: MGI:MGI:1916557
See related: Ensembl:ENSMUSG00000045378 AllianceGenome:MGI:1916557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stepp; 1700001G18Rik
Summary: Involved in spermatogenesis. Acts upstream of or within positive regulation of apoptotic process. Located in nucleus and peroxisome. Is expressed in foregut; nervous system; sensory organ; and submandibular gland primordium. Orthologous to human PXT1 (peroxisomal testis enriched protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 71.2) See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29152960..29161236, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28933986..28942262, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Pxt1 expression is regulated by Mir6996 miRNA.
Title: Mouse Pxt1 expression is regulated by Mir6996 miRNA.
Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice.
Title: Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice.
PXT1 induces apoptosis via the BH3-like domain and that this process is inhibited by BAT3
Title: Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice.
Pxt1 gene is so far the first gene coding for a putative peroxisomal protein which is expressed in later steps of spermatogenesis, namely in pachytene spermatocytes
Title: The putative peroxisomal gene Pxt1 is exclusively expressed in the testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxisomal testis-specific protein 1

Names: small testis-specific peroxisomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.