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br broad-complex core protein [ Bombyx mori (domestic silkworm) ]

Gene ID: 692523, updated on 10-Oct-2024

Summary

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Gene symbol
br
Gene description
broad-complex core protein
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bombyx mori
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
Also known as
Br-c
Orthologs
fruit fly all
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Genomic context

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Location:
chromosome: 8
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 8 NC_085114.1 (15276515..15459293)
103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 8 NC_051365.1 (15243222..15426001)

Chromosome 8 - NC_085114.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101744165 Neighboring gene uncharacterized LOC105843018 Neighboring gene uncharacterized LOC119628793 Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene microRNA mir-3251 Neighboring gene DExD-box helicase 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae. Ding N, et al. J Insect Physiol, 2020 Apr. PMID 32126216
  2. Construction and characterization of bacterial artificial chromosome libraries from the silkworm, Bombyx mori. Wu C, et al. Mol Gen Genet, 1999 Jun. PMID 10394907
  3. Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis. Uhlirova M, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14668449, Free PMC Article
  4. cDNA cloning, gene structure, and expression of Broad-Complex (BR-C) genes in the silkworm, Bombyx mori. Ijiro T, et al. Insect Biochem Mol Biol, 2004 Sep. PMID 15350615
  5. Structure and expression of the gene encoding a Broad-Complex homolog in the silkworm, Bombyx mori. Nishita Y, et al. Gene, 2004 Sep 15. PMID 15363856

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide identification of target genes for transcription factor BR-C in the silkworm, Bombyx mori.
    Title: Genome-wide identification of target genes for transcription factor BR-C in the silkworm, Bombyx mori.
  2. Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae.
    Title: Silencing Br-C impairs larval development and chitin synthesis in Lymantria dispar larvae.
  3. Broad-Complex Z4 (BR-C Z4) was up-regulated by 20-hydroxyecdysone just before pupation, while transcription factor FoxJ and CHSA-2b were up-regulated during the pupal stage.
    Title: BR-C Z4 and FoxJ interact to regulate expression of a chitin synthase gene CHSA-2b in the pupal wing discs of the silkworm, Bombyx mori.
  4. findings indicate that PKA-mediated phosphorylation inhibits silkworm BR-C activity by interfering with its binding to DNA and that 20E signaling relieves PKA-mediated phosphorylation of BR-C, thereby maintaining its transcriptional activity
    Title: Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity.
  5. transcription factor BR-C Z4 enhances the expression of chitinase 5 during metamorphosis
    Title: 20-hydroxyecdysone enhances the expression of the chitinase 5 via Broad-Complex Zinc-Finger 4 during metamorphosis in silkworm, Bombyx mori.
  6. longitudinals lacking (lola), tramtrack (ttk), broad complex (br), and fruitless (fru) are BTB-C2H2 zinc finger proteins conserved in different insects
    Title: The Fruitless gene in Nasonia displays complex sex-specific splicing and contains new zinc finger domains.
  7. In larvae, uvenile hormone induced the expression of Kr-h1 and concurrently suppressed 20-hydroxyecdysone-induced expression of BR-C.
    Title: Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene.
  8. The PKC-mediated phosphorylation and nuclear import of BR-C is determined by its interaction with RACK1.
    Title: Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.
  9. BR-C Z2 regulated the transcription of BMWCP10.
    Title: Activation of BMWCP10 promoter and regulation by BR-C Z2 in wing disc of Bombyx mori.
  10. BMWCP5 transcription is primarily regulated by FTZ-F1, and the stage-specific enhancement is brought about through BR-Z4.
    Title: betaFTZ-F1 and Broad-Complex positively regulate the transcription of the wing cuticle protein gene, BMWCP5, in wing discs of Bombyx mori.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
broad-complex core protein; broad-complex
Names
broad

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043511.1 → NP_001036976.1  broad-complex core protein isoform Z4

    See identical proteins and their annotated locations for NP_001036976.1

    Status: PROVISIONAL

    Source sequence(s)
    AB181191
    UniProtKB/TrEMBL
    Q6I6N4, Q6I7P3
    Conserved Domains (2) summary
    sd00017
    Location:364 → 390
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 119
    BTB; BTB/POZ domain

  2. NM_001111333.1 → NP_001104803.1  broad-complex core protein isoform Z2

    See identical proteins and their annotated locations for NP_001104803.1

    Status: PROVISIONAL

    Source sequence(s)
    AB113087
    UniProtKB/TrEMBL
    Q65YS5, Q6I7P4
    Conserved Domains (2) summary
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

  3. NM_001111334.1 → NP_001104804.1  broad-complex core protein isoform Z1

    See identical proteins and their annotated locations for NP_001104804.1

    Status: PROVISIONAL

    Source sequence(s)
    AB181189
    UniProtKB/TrEMBL
    Q65YS5, Q6I7P6
    Conserved Domains (2) summary
    sd00020
    Location:366 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM3026992v2 Primary Assembly

Genomic

  1. NC_085114.1 Reference ASM3026992v2 Primary Assembly

    Range
    15276515..15459293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021346252.3 → XP_021201927.1  broad-complex isoform X1

    UniProtKB/TrEMBL
    A0A8R2QZD6
    Conserved Domains (3) summary
    sd00017
    Location:375 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    pfam17772
    Location:385 → 423
    zf-MYST; MYST family zinc finger domain

  2. XM_021346254.3 → XP_021201929.1  broad-complex isoform X1

    UniProtKB/TrEMBL
    A0A8R2QZD6
    Conserved Domains (3) summary
    sd00017
    Location:375 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    pfam17772
    Location:385 → 423
    zf-MYST; MYST family zinc finger domain

  3. XM_062669542.1 → XP_062525526.1  broad-complex isoform X2

    UniProtKB/TrEMBL
    Q6I6N4

  4. XM_021346253.3 → XP_021201928.1  broad-complex isoform X1

    UniProtKB/TrEMBL
    A0A8R2QZD6
    Conserved Domains (3) summary
    sd00017
    Location:375 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    pfam17772
    Location:385 → 423
    zf-MYST; MYST family zinc finger domain

  5. XM_021346258.3 → XP_021201933.1  broad-complex isoform X3

    UniProtKB/TrEMBL
    Q65YS5, Q6I7P6
    Conserved Domains (2) summary
    sd00020
    Location:366 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

  6. XM_021346257.3 → XP_021201932.1  broad-complex isoform X2

    UniProtKB/TrEMBL
    Q6I6N4, Q6I7P3
    Conserved Domains (2) summary
    sd00017
    Location:364 → 390
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 119
    BTB; BTB/POZ domain

  7. XM_021346256.3 → XP_021201931.1  broad-complex isoform X1

    UniProtKB/TrEMBL
    A0A8R2QZD6
    Conserved Domains (3) summary
    sd00017
    Location:375 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    pfam17772
    Location:385 → 423
    zf-MYST; MYST family zinc finger domain

  8. XM_038012249.2 → XP_037868177.1  broad-complex isoform X1

    UniProtKB/TrEMBL
    A0A8R2QZD6
    Conserved Domains (3) summary
    sd00017
    Location:375 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    pfam17772
    Location:385 → 423
    zf-MYST; MYST family zinc finger domain

  9. XM_062669541.1 → XP_062525525.1  broad-complex isoform X2

    UniProtKB/TrEMBL
    Q6I6N4

  10. XM_038012250.2 → XP_037868178.1  broad-complex isoform X1

    UniProtKB/TrEMBL
    A0A8R2QZD6
    Conserved Domains (3) summary
    sd00017
    Location:375 → 396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18315
    Location:33 → 116
    BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    pfam17772
    Location:385 → 423
    zf-MYST; MYST family zinc finger domain

  11. XM_062669543.1 → XP_062525527.1  broad-complex isoform X3

    UniProtKB/TrEMBL
    Q6I7P6
Nucleotide Protein
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