Scimp SLP adaptor and CSK interacting membrane protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scimpprovided by RGD
Official Full Name: SLP adaptor and CSK interacting membrane proteinprovided by RGD
Primary source: RGD:1593299
See related: EnsemblRapid:ENSRNOG00000037409 AllianceGenome:RGD:1593299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in several processes, including pattern recognition receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in several cellular components, including ruffle; tetraspanin-enriched microdomain; and uropod membrane. Predicted to be part of receptor complex. Predicted to be active in immunological synapse. Orthologous to human SCIMP (SLP adaptor and CSK interacting membrane protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 54.8), Spleen (RPKM 41.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (56006243..56026357, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55507646..55527764, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57415429..57436412, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to molecule of fungal origin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor TLR1:TLR2 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in immunological synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info
located_in uropod membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SLP adapter and CSK-interacting membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398998.1 → NP_001385927.1 SLP adapter and CSK-interacting membrane protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

F1LYV1

Related

ENSRNOP00000107402.1, ENSRNOT00000132507.1

Conserved Domains (1) summary

pfam15050
Location:1 → 132

SCIMP; SCIMP protein