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TCEA2 transcription elongation factor A2 [ Homo sapiens (human) ]

Gene ID: 6919, updated on 7-Apr-2024

Summary

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Official Symbol
TCEA2provided by HGNC
Official Full Name
transcription elongation factor A2provided by HGNC
Primary source
HGNC:HGNC:11614
See related
Ensembl:ENSG00000171703 MIM:604784; AllianceGenome:HGNC:11614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIS
Summary
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 9.5), brain (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

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See TCEA2 in Genome Data Viewer
Location:
20q13.33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64055596..64072347)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65875622..65892426)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62688325..62703700)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62667815-62668408 Neighboring gene chromosome 20 open reading frame 204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62668409-62669002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62676871-62677791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13204 Neighboring gene SOX18 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62684293-62684982 Neighboring gene SRY-box transcription factor 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62686363-62687052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62687053-62687742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62688433-62689122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62689123-62689810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13207 Neighboring gene regulator of G protein signaling 19 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62711846-62712019 Neighboring gene microRNA 6813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13209 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. Sijbrandi R, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034815, Free PMC Article
  2. Genomic characterization of a testis-specific TFIIS (TCEA2) gene. Weaver ZA, et al. Genomics, 1997 Dec 15. PMID 9441762
  3. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. Kuraoka I, et al. DNA Repair (Amst), 2007 Jun 1. PMID 17374514
  4. PITSLRE p110 protein kinases associate with transcription complexes and affect their activity. Trembley JH, et al. J Biol Chem, 2002 Jan 25. PMID 11709559
  5. A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. Palangat M, et al. Proc Natl Acad Sci U S A, 2005 Oct 18. PMID 16214896, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SII is important for preventing cellular death due to oxidative DNA damage, assisting RNAPII to bypass 8-oxoG
    Title: RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.
  2. RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage.
    Title: RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage.
  3. data suggest that because TFIIS promotes escape from promoter-proximal pauses by stimulating cleavage of back-tracked nascent RNA, TFIIS inhibition may help DSIF/NELF negatively regulate productive transcription
    Title: A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription elongation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription elongation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription elongation factor complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription elongation factor A protein 2
Names
testis-specific S-II
transcription elongation factor A (SII), 2
transcription elongation factor S-II protein 2
transcription elongation factor TFIIS.1
transcription elongation factor TFIIS.l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003195.6 → NP_003186.1  transcription elongation factor A protein 2 isoform a

    See identical proteins and their annotated locations for NP_003186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC018896, CA440059, DB482075
    Consensus CDS
    CCDS13553.1
    UniProtKB/Swiss-Prot
    B3KNM1, Q15560, Q8TD37, Q8TD38
    UniProtKB/TrEMBL
    A0A0A0MT58, Q6IB64
    Related
    ENSP00000343515.5, ENST00000343484.10
    Conserved Domains (1) summary
    cl02637
    Location:6 → 299
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  2. NM_198723.2 → NP_942016.1  transcription elongation factor A protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC018896, BI756937, CA440059, CB961240
    Consensus CDS
    CCDS13554.1
    UniProtKB/TrEMBL
    A0A0A0MT58
    Related
    ENSP00000354552.2, ENST00000361317.6
    Conserved Domains (1) summary
    cl02637
    Location:1 → 272
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    64055596..64072347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440438.1 → XP_047296394.1  transcription elongation factor A protein 2 isoform X2

  2. XM_024451981.2 → XP_024307749.1  transcription elongation factor A protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MT58
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 270
    TFSII; transcription elongation factor S-II

  3. XM_047440432.1 → XP_047296388.1  transcription elongation factor A protein 2 isoform X2

  4. XM_047440433.1 → XP_047296389.1  transcription elongation factor A protein 2 isoform X2

  5. XM_024451976.2 → XP_024307744.1  transcription elongation factor A protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MT58
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 270
    TFSII; transcription elongation factor S-II

  6. XM_047440436.1 → XP_047296392.1  transcription elongation factor A protein 2 isoform X2

  7. XM_024451984.1 → XP_024307752.1  transcription elongation factor A protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MT58
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 270
    TFSII; transcription elongation factor S-II

  8. XM_047440434.1 → XP_047296390.1  transcription elongation factor A protein 2 isoform X2

  9. XM_047440437.1 → XP_047296393.1  transcription elongation factor A protein 2 isoform X2

  10. XM_047440431.1 → XP_047296387.1  transcription elongation factor A protein 2 isoform X2

  11. XM_047440441.1 → XP_047296397.1  transcription elongation factor A protein 2 isoform X3

  12. XM_047440435.1 → XP_047296391.1  transcription elongation factor A protein 2 isoform X2

  13. XM_024451983.2 → XP_024307751.1  transcription elongation factor A protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MT58
    Related
    ENSP00000339432.4, ENST00000339217.8
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 270
    TFSII; transcription elongation factor S-II

  14. XM_047440439.1 → XP_047296395.1  transcription elongation factor A protein 2 isoform X2

    Related
    ENSP00000407085.1, ENST00000440819.5

  15. XM_024451985.2 → XP_024307753.1  transcription elongation factor A protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MT58
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 270
    TFSII; transcription elongation factor S-II

  16. XM_047440440.1 → XP_047296396.1  transcription elongation factor A protein 2 isoform X2

  17. XM_005260229.5 → XP_005260286.1  transcription elongation factor A protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005260286.1

    UniProtKB/TrEMBL
    A0A0A0MT58
    Conserved Domains (4) summary
    cd00183
    Location:5 → 81
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:252 → 297
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:6 → 297
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:136 → 243
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  18. XM_047440430.1 → XP_047296386.1  transcription elongation factor A protein 2 isoform X2

  19. XM_047440442.1 → XP_047296398.1  transcription elongation factor A protein 2 isoform X3

  20. XM_024451986.2 → XP_024307754.1  transcription elongation factor A protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MT58
    Related
    ENSP00000416026.1, ENST00000458442.1
    Conserved Domains (1) summary
    TIGR01385
    Location:1 → 270
    TFSII; transcription elongation factor S-II

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65875622..65892426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323951.1 → XP_054179926.1  transcription elongation factor A protein 2 isoform X2

  2. XM_054323943.1 → XP_054179918.1  transcription elongation factor A protein 2 isoform X2

  3. XM_054323944.1 → XP_054179919.1  transcription elongation factor A protein 2 isoform X2

  4. XM_054323946.1 → XP_054179921.1  transcription elongation factor A protein 2 isoform X2

  5. XM_054323949.1 → XP_054179924.1  transcription elongation factor A protein 2 isoform X2

  6. XM_054323950.1 → XP_054179925.1  transcription elongation factor A protein 2 isoform X2

  7. XM_054323945.1 → XP_054179920.1  transcription elongation factor A protein 2 isoform X2

  8. XM_054323948.1 → XP_054179923.1  transcription elongation factor A protein 2 isoform X2

  9. XM_054323956.1 → XP_054179931.1  transcription elongation factor A protein 2 isoform X3

  10. XM_054323947.1 → XP_054179922.1  transcription elongation factor A protein 2 isoform X2

  11. XM_054323953.1 → XP_054179928.1  transcription elongation factor A protein 2 isoform X2

  12. XM_054323952.1 → XP_054179927.1  transcription elongation factor A protein 2 isoform X2

  13. XM_054323954.1 → XP_054179929.1  transcription elongation factor A protein 2 isoform X2

  14. XM_054323955.1 → XP_054179930.1  transcription elongation factor A protein 2 isoform X2

  15. XM_054323941.1 → XP_054179916.1  transcription elongation factor A protein 2 isoform X1

  16. XM_054323957.1 → XP_054179932.1  transcription elongation factor A protein 2 isoform X3

  17. XM_054323942.1 → XP_054179917.1  transcription elongation factor A protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15560.1 GenPept UniProtKB/Swiss-Prot:Q15560

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