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Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691853, updated on 2-Nov-2024

Summary

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Official Symbol
Cox10provided by RGD
Official Full Name
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10provided by RGD
Primary source
RGD:1594623
See related
EnsemblRapid:ENSRNOG00000024972 AllianceGenome:RGD:1594623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable farnesyltranstransferase activity and protoheme IX farnesyltransferase activity. Predicted to be involved in heme A biosynthetic process; heme O biosynthetic process; and respiratory chain complex IV assembly. Predicted to act upstream of or within several processes, including copper ion homeostasis; cytochrome complex assembly; and mitochondrial fission. Predicted to be located in cytosol and nucleolus. Predicted to be part of cytochrome complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 135.1), Muscle (RPKM 106.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cox10 in Genome Data Viewer
Location:
10q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (49130209..49242009, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (48630993..48742805, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (50439778..50563920, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095117 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 3B1 Neighboring gene uncharacterized LOC120095119 Neighboring gene uncharacterized LOC120095118 Neighboring gene transfer RNA glutamine (anticodon CUG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts. Diaz F, et al. Mol Cell Biol, 2006 Jul. PMID 16782876, Free PMC Article
  2. Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency. Antonicka H, et al. Hum Mol Genet, 2003 Oct 15. PMID 12928484
  3. A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiency. Valnot I, et al. Hum Mol Genet, 2000 May 1. PMID 10767350
  4. Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant. Glerum DM, et al. Proc Natl Acad Sci U S A, 1994 Aug 30. PMID 8078902, Free PMC Article
  5. Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1. Williams SL, et al. J Biol Chem, 2004 Feb 27. PMID 14607829

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables farnesyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protoheme IX farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protoheme IX farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aerobic respiration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within copper ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytochrome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in heme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory chain complex IV assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cytochrome complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
Names
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
cytochrome c oxidase assembly homolog 10
protoheme IX farnesyltransferase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398997.1 → NP_001385926.1  cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HFE3
    Related
    ENSRNOP00000029439.6, ENSRNOT00000034261.7
    Conserved Domains (1) summary
    cd13957
    Location:158 → 413
    PT_UbiA_Cox10; Protoheme IX farnesyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    49130209..49242009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269908.1 → XP_063125978.1  cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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