Tmem107 transmembrane protein 107 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem107provided by RGD
Official Full Name: transmembrane protein 107provided by RGD
Primary source: RGD:1595972
See related: EnsemblRapid:ENSRNOG00000006519 AllianceGenome:RGD:1595972
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including embryonic digit morphogenesis; non-motile cilium assembly; and protein localization to ciliary transition zone. Predicted to act upstream of or within several processes, including craniofacial suture morphogenesis; detection of nodal flow; and roof of mouth development. Predicted to be located in ciliary transition zone. Predicted to be part of MKS complex. Human ortholog(s) of this gene implicated in Meckel syndrome 13 and orofaciodigital syndrome XVI. Orthologous to human TMEM107 (transmembrane protein 107). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 83.4), Spleen (RPKM 57.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54268218..54273520)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53772153..53774685)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55653694..55656270)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of nodal flow	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neural tube patterning	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to ciliary transition zone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MKS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MKS complex	IEA Inferred from Electronic Annotation more info
part_of MKS complex	ISO Inferred from Sequence Orthology more info
part_of MKS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109648.1 → NP_001103118.1 transmembrane protein 107

See identical proteins and their annotated locations for NP_001103118.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

D3ZFW5

Conserved Domains (1) summary

pfam14995
Location:7 → 129

TMEM107; Transmembrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54268218..54273520

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597537.3 → XP_017453026.1 transmembrane protein 107 isoform X4
XM_063269903.1 → XP_063125973.1 transmembrane protein 107 isoform X1
XM_017597538.3 → XP_017453027.1 transmembrane protein 107 isoform X5

UniProtKB/TrEMBL

A6HFN0

Conserved Domains (1) summary

pfam14995
Location:7 → 137

TMEM107; Transmembrane protein
XM_017597539.3 → XP_017453028.1 transmembrane protein 107 isoform X7
XM_006246808.5 → XP_006246870.1 transmembrane protein 107 isoform X6

Related

ENSRNOP00000099873.1, ENSRNOT00000170020.1

Conserved Domains (1) summary

pfam14995
Location:7 → 89

TMEM107; Transmembrane protein
XM_039086901.2 → XP_038942829.1 transmembrane protein 107 isoform X9

Related

ENSRNOP00000089825.2, ENSRNOT00000106758.2
XM_063269904.1 → XP_063125974.1 transmembrane protein 107 isoform X2
XM_063269907.1 → XP_063125977.1 transmembrane protein 107 isoform X8

UniProtKB/TrEMBL

A0A8I6ACI6, A6HFN2
XM_006246811.5 → XP_006246873.1 transmembrane protein 107 isoform X10

Conserved Domains (1) summary

pfam14995
Location:7 → 79

TMEM107; Transmembrane protein
XM_063269905.1 → XP_063125975.1 transmembrane protein 107 isoform X3
XM_006246812.5 → XP_006246874.1 transmembrane protein 107 isoform X11

See identical proteins and their annotated locations for XP_006246874.1

UniProtKB/TrEMBL

A6HFN3

Conserved Domains (1) summary

pfam14995
Location:7 → 119

TMEM107; Transmembrane protein
XM_039086902.2 → XP_038942830.1 transmembrane protein 107 isoform X12

Conserved Domains (1) summary

pfam14995
Location:7 → 112

TMEM107; Transmembrane protein