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Sbk2 SH3 domain binding kinase family, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691411, updated on 2-Nov-2024

Summary

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Official Symbol
Sbk2provided by RGD
Official Full Name
SH3 domain binding kinase family, member 2provided by RGD
Primary source
RGD:1563279
See related
EnsemblRapid:ENSRNOG00000038625 AllianceGenome:RGD:1563279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563279
Summary
Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Orthologous to human SBK2 (SH3 domain binding kinase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 55.3), Muscle (RPKM 42.7) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sbk2 in Genome Data Viewer
Location:
1q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (77902926..77910758)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68874081..68881918)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72425728..72433494)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 579 Neighboring gene SH3 domain binding kinase family, member 3 Neighboring gene scavenger receptor cysteine rich family member with 5 domains Neighboring gene N-acetyltransferase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC187475

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase SBK2
Names
SH3-binding domain kinase family, member 2
NP_001121011.1
XP_038947471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127539.2 → NP_001121011.1  serine/threonine-protein kinase SBK2

    See identical proteins and their annotated locations for NP_001121011.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161893
    UniProtKB/Swiss-Prot
    B1WBU5
    Conserved Domains (1) summary
    cl21453
    Location:68 → 329
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    77902926..77910758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091543.2 → XP_038947471.1  serine/threonine-protein kinase SBK2 isoform X1

    UniProtKB/Swiss-Prot
    B1WBU5
    Related
    ENSRNOP00000055736.2, ENSRNOT00000058956.5
    Conserved Domains (1) summary
    cl21453
    Location:68 → 329
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WBU5.1 GenPept UniProtKB/Swiss-Prot:B1WBU5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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