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Ulk3 unc-51 like kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691171, updated on 18-Sep-2024

Summary

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Official Symbol
Ulk3provided by RGD
Official Full Name
unc-51 like kinase 3provided by RGD
Primary source
RGD:1587417
See related
EnsemblRapid:ENSRNOG00000038459 AllianceGenome:RGD:1587417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including fibroblast activation; protein phosphorylation; and regulation of smoothened signaling pathway. Predicted to be active in autophagosome. Orthologous to human ULK3 (unc-51 like kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 28.5), Thymus (RPKM 21.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ulk3 in Genome Data Viewer
Location:
8q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66888820..66895380)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57992396..58000220)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62368548..62375229)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 55 Neighboring gene mannose phosphate isomerase Neighboring gene secretory carrier membrane protein 2 Neighboring gene complexin 3 Neighboring gene lectin, mannose-binding, 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI. Goruppi S, et al. Cell Rep, 2017 Sep 5. PMID 28877478, Free PMC Article
  2. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Maloverjan A, et al. Exp Cell Res, 2010 Feb 15. PMID 19878745
  3. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. Maloverjan A, et al. J Biol Chem, 2010 Sep 24. PMID 20643644, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.
    Title: Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast activation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase ULK3
NP_001258064.1
XP_017451411.1
XP_038938114.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271135.1 → NP_001258064.1  serine/threonine-protein kinase ULK3

    See identical proteins and their annotated locations for NP_001258064.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    D3ZHP7
    UniProtKB/TrEMBL
    A0A8I6AFV1
    Related
    ENSRNOP00000025885.2, ENSRNOT00000025885.6
    Conserved Domains (4) summary
    smart00220
    Location:14 → 270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:279 → 353
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cd14121
    Location:18 → 269
    STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3
    cl00299
    Location:374 → 449
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66888820..66895380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082186.2 → XP_038938114.1  serine/threonine-protein kinase ULK3 isoform X2

    UniProtKB/TrEMBL
    A6J4W6
    Conserved Domains (3) summary
    cd02684
    Location:171 → 245
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl00299
    Location:266 → 341
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:14 → 161
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017595922.3 → XP_017451411.1  serine/threonine-protein kinase ULK3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFV1
    Related
    ENSRNOP00000095197.1, ENSRNOT00000096845.2

RNA

  1. XR_356333.5 RNA Sequence

  2. XR_005487924.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZHP7.1 GenPept UniProtKB/Swiss-Prot:D3ZHP7

Gene LinkOut

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