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Fbxo3 F-box protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690634, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxo3provided by RGD
Official Full Name
F-box protein 3provided by RGD
Primary source
RGD:1593433
See related
EnsemblRapid:ENSRNOG00000009549 AllianceGenome:RGD:1593433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and response to lipopolysaccharide. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO3 (F-box protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 201.8), Heart (RPKM 159.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxo3 in Genome Data Viewer
Location:
3q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (110872185..110904479)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (90417262..90449557)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93968827..94000863)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101615 Neighboring gene uncharacterized LOC102551977 Neighboring gene uncharacterized LOC102552075 Neighboring gene LIM domain only 2 Neighboring gene uncharacterized LOC108350426 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene CD59b molecule Neighboring gene similar to human chromosome 11 open reading frame 91

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Gao Y, et al. Int J Mol Sci, 2022 Nov 7. PMID 36362432, Free PMC Article
  2. miR-219a-5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3. Wang Q, et al. Environ Toxicol, 2022 Nov. PMID 35962723
  3. Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade. Lin TB, et al. J Neurosci, 2015 Dec 16. PMID 26674878, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
    Title: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
  2. miR-219a-5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3.
    Title: miR-219a-5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3.
  3. F-box protein 3 modifies the neuropathic pain pathway by inhibiting F-box and leucine-rich repeat protein 2-mediated TRAF2 ubiquitination
    Title: Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109606.1 → NP_001103076.1  F-box only protein 3

    See identical proteins and their annotated locations for NP_001103076.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/Swiss-Prot
    D4ABP9
    UniProtKB/TrEMBL
    A6HNT3
    Related
    ENSRNOP00000014478.2, ENSRNOT00000014478.6
    Conserved Domains (3) summary
    pfam04379
    Location:294 → 383
    DUF525; ApaG domain
    pfam09346
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:13 → 57
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    110872185..110904479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234657.5 → XP_006234719.1  F-box only protein 3 isoform X2

    UniProtKB/TrEMBL
    A6HNT3
    Conserved Domains (3) summary
    pfam04379
    Location:294 → 383
    DUF525; ApaG domain
    pfam09346
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:13 → 57
    F-box-like

  2. XM_006234656.5 → XP_006234718.1  F-box only protein 3 isoform X1

    UniProtKB/TrEMBL
    A6HNT3
    Conserved Domains (3) summary
    pfam04379
    Location:294 → 383
    DUF525; ApaG domain
    pfam09346
    Location:121 → 249
    SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)
    pfam12937
    Location:13 → 57
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4ABP9.1 GenPept UniProtKB/Swiss-Prot:D4ABP9

Gene LinkOut

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