Ttll4 tubulin tyrosine ligase like 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttll4provided by RGD
Official Full Name: tubulin tyrosine ligase like 4provided by RGD
Primary source: RGD:1594742
See related: EnsemblRapid:ENSRNOG00000017129 AllianceGenome:RGD:1594742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and peptidyl-glutamic acid modification. Predicted to act upstream of or within protein polyglutamylation and regulation of blastocyst development. Predicted to be located in 9+0 non-motile cilium. Predicted to be active in ciliary basal body. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 73.1), Thymus (RPKM 49.3) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9q33

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83670788..83706891)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76221659..76258219)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (81925363..81961882)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-glutamic acid ligase activity	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin-glutamic acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-glutamic acid modification	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein polyglutamylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein polyglutamylation	ISO Inferred from Sequence Orthology more info
involved_in protein polyglutamylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blastocyst development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+0 non-motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: tubulin monoglutamylase TTLL4

Names: tubulin polyglutamylase TTLL4; tubulin tyrosine ligase-like family, member 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.