Il15ra interleukin 15 receptor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il15raprovided by RGD
Official Full Name: interleukin 15 receptor subunit alphaprovided by RGD
Primary source: RGD:1305149
See related: Ensembl:ENSRNOG00000018706 AllianceGenome:RGD:1305149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Involved in negative regulation of neuron projection development; receptor signaling pathway via JAK-STAT; and response to nutrient levels. Predicted to be located in cell surface and cytoplasmic vesicle. Predicted to be active in plasma membrane. Orthologous to human IL15RA (interleukin 15 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 35.1), Adrenal (RPKM 23.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71712141..71742072, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66802300..66831973, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (70451861..70481838, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-15 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-15 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-15-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-15 receptor subunit alpha

Names: interleukin 15 receptor, alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100801.1 → NP_001094271.1 interleukin-15 receptor subunit alpha precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6AI14, A6JLR7, F1M293

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

71712141..71742072 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276767.1 → XP_063132837.1 interleukin-15 receptor subunit alpha isoform X4

UniProtKB/TrEMBL

A6JLR8
XM_063276766.1 → XP_063132836.1 interleukin-15 receptor subunit alpha isoform X3
XM_063276765.1 → XP_063132835.1 interleukin-15 receptor subunit alpha isoform X1
XM_006254225.5 → XP_006254287.1 interleukin-15 receptor subunit alpha isoform X2

See identical proteins and their annotated locations for XP_006254287.1

UniProtKB/TrEMBL

A0A8I6ADB7, A0A8I6G839

Related

ENSRNOP00000081543.1

Conserved Domains (1) summary

cd00033
Location:38 → 99

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system