U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spcs1 signal peptidase complex subunit 1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 69019, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Spcs1provided by MGI
Official Full Name
signal peptidase complex subunit 1 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1916269
See related
Ensembl:ENSMUSG00000021917 AllianceGenome:MGI:1916269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810004F21Rik
Summary
Enables ribosome binding activity. Predicted to be involved in several processes, including protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; ear; integumental system; and nervous system. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 218.3), placenta adult (RPKM 69.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Spcs1 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30721783..30723330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30999826..31001666, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene predicted gene, 24916 Neighboring gene guanine nucleotide binding protein nucleolar 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Hori O, et al. Mol Cell Biol, 2006 Jun. PMID 16705175, Free PMC Article
  2. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. Kalies KU, et al. J Biol Chem, 1996 Feb 16. PMID 8632014
  3. Little skate genome provides insights into genetic programs essential for limb-based locomotion. Yoo D, et al. Elife, 2022 Oct 26. PMID 36288084, Free PMC Article
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
  
involved_in viral protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in virion assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
signal peptidase complex subunit 1
Names
SPase 12 kDa subunit
microsomal signal peptidase 12 kDa subunit
NP_081187.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026911.4 → NP_081187.3  signal peptidase complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AC154727
    Consensus CDS
    CCDS26903.2
    UniProtKB/TrEMBL
    A0A2I3BRW0
    Related
    ENSMUSP00000154732.2, ENSMUST00000228736.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30721783..30723330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D958.3 GenPept UniProtKB/Swiss-Prot:Q9D958

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous