Tatdn3 TatD DNase domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tatdn3provided by MGI
Official Full Name: TatD DNase domain containing 3provided by MGI
Primary source: MGI:MGI:1916222
See related: Ensembl:ENSMUSG00000026632 AllianceGenome:MGI:1916222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500010M24Rik
Summary: Predicted to enable metal ion binding activity and nuclease activity. Located in mitochondrion. Orthologous to human TATDN3 (TatD DNase domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.28 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (190778023..190795373, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (191045826..191063075, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative deoxyribonuclease TATDN3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163421.1 → NP_001156893.1 putative deoxyribonuclease TATDN3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC138229

Consensus CDS

CCDS48486.1

UniProtKB/TrEMBL

D3Z0V5

Related

ENSMUSP00000106516.2, ENSMUST00000110891.8

Conserved Domains (1) summary

cd01310
Location:5 → 223

TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
NM_001163422.1 → NP_001156894.1 putative deoxyribonuclease TATDN3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC138229

Consensus CDS

CCDS48484.1

UniProtKB/Swiss-Prot

Q3U1C6

Related

ENSMUSP00000082773.6, ENSMUST00000085633.12

Conserved Domains (1) summary

cl00281
Location:5 → 158

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
NM_001357166.1 → NP_001344095.1 putative deoxyribonuclease TATDN3 isoform 4

Status: VALIDATED

Source sequence(s)

AC138229

Consensus CDS

CCDS87944.1

UniProtKB/Swiss-Prot

Q3U1C6, Q6P8H6, Q9DB58

UniProtKB/TrEMBL

D3YXH9

Related

ENSMUSP00000027945.6, ENSMUST00000027945.6

Conserved Domains (1) summary

cd01310
Location:5 → 261

TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
NM_026895.1 → NP_081171.1 putative deoxyribonuclease TATDN3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC138229

Consensus CDS

CCDS48485.1

UniProtKB/Swiss-Prot

Q3U1C6, Q6P8H6, Q9DB58

UniProtKB/TrEMBL

E9QL22

Related

ENSMUSP00000106518.4, ENSMUST00000110893.10

Conserved Domains (2) summary

COG1099
Location:6 → 262

COG1099; Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]

cd01310
Location:5 → 262

TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

190778023..190795373 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497204.5 → XP_006497267.1 putative deoxyribonuclease TATDN3 isoform X1

Conserved Domains (1) summary

cl00281
Location:51 → 209

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...