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Tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog [ Mus musculus (house mouse) ]

Gene ID: 68971, updated on 2-Nov-2024

Summary

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Official Symbol
Tamm41provided by MGI
Official Full Name
TAM41 mitochondrial translocator assembly and maintenance homologprovided by MGI
Primary source
MGI:MGI:1916221
See related
Ensembl:ENSMUSG00000030316 AllianceGenome:MGI:1916221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAM41; 1500001M20Rik
Summary
Predicted to enable phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and cardiolipin biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 56. Orthologous to human TAMM41 (TAM41 mitochondrial translocator assembly and maintenance homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 17.1), ovary adult (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tamm41 in Genome Data Viewer
Location:
6 E3; 6 53.14 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114981342..115014890, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115004381..115037929, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vestigial like family member 4 Neighboring gene predicted gene, 38876 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene predicted gene, 52944 Neighboring gene STARR-seq mESC enhancer starr_17075 Neighboring gene STARR-positive B cell enhancer ABC_E6470 Neighboring gene predicted gene, 36190 Neighboring gene predicted gene, 17733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidate cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidate cytidylyltransferase, mitochondrial
Names
CDP-DAG synthase
CDP-diacylglycerol synthase
MMP37-like protein, mitochondrial
TAM41, mitochondrial translocator assembly and maintenance protein, homolog
mitochondrial translocator assembly and maintenance protein 41 homolog
NP_081170.1
XP_006506615.1
XP_006506616.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026894.1 → NP_081170.1  phosphatidate cytidylyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_081170.1

    Status: VALIDATED

    Source sequence(s)
    AK005100, BB857425, BE956902
    Consensus CDS
    CCDS20437.1
    UniProtKB/Swiss-Prot
    Q3TUH1
    UniProtKB/TrEMBL
    G5E881
    Related
    ENSMUSP00000032461.6, ENSMUST00000032461.12
    Conserved Domains (1) summary
    pfam09139
    Location:13 → 327
    Mmp37; Mitochondrial matrix Mmp37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114981342..115014890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506552.2 → XP_006506615.1  phosphatidate cytidylyltransferase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3TUH1
    Conserved Domains (1) summary
    pfam09139
    Location:13 → 277
    Mmp37; Mitochondrial matrix Mmp37

  2. XM_006506553.5 → XP_006506616.1  phosphatidate cytidylyltransferase, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam09139
    Location:3 → 185
    Mmp37; Mitochondrial matrix Mmp37

RNA

  1. XR_377489.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TUH1.2 GenPept UniProtKB/Swiss-Prot:Q3TUH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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