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Ubap2 ubiquitin-associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68926, updated on 2-Nov-2024

Summary

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Official Symbol
Ubap2provided by MGI
Official Full Name
ubiquitin-associated protein 2provided by MGI
Primary source
MGI:MGI:1916176
See related
Ensembl:ENSMUSG00000028433 AllianceGenome:MGI:1916176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBAP-2; mKIAA1491; 1190005K07Rik
Summary
Predicted to be located in chromosome. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBAP2 (ubiquitin associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 65.5), thymus adult (RPKM 28.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ubap2 in Genome Data Viewer
Location:
4 A5; 4 21.13 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41194313..41276016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41194313..41276016, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E150 Neighboring gene STARR-positive B cell enhancer ABC_E6162 Neighboring gene nucleolar protein family 6 (RNA-associated) Neighboring gene ubiquitin-conjugating enzyme E2R 2 Neighboring gene STARR-seq mESC enhancer starr_10025 Neighboring gene predicted gene, 22888 Neighboring gene predicted gene, 24837 Neighboring gene predicted gene, 23090 Neighboring gene predicted gene 12401 Neighboring gene STARR-positive B cell enhancer ABC_E2108 Neighboring gene predicted gene, 42273 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E7963 Neighboring gene predicted gene, 26049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.
    Title: Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.
  2. UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis.
    Title: UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-associated protein 2
Names
MLig-1
RNA polymerase II degradation factor Ubap2
protein lingerer homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419187.1 → NP_001406116.1  ubiquitin-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807823

  2. NM_001419188.1 → NP_001406117.1  ubiquitin-associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807823

  3. NM_001419189.1 → NP_001406118.1  ubiquitin-associated protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807823
    Related
    ENSMUSP00000121724.2, ENSMUST00000134782.2

  4. NM_001419190.1 → NP_001406119.1  ubiquitin-associated protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL807823

  5. NM_001419191.1 → NP_001406120.1  ubiquitin-associated protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL807823

  6. NM_026872.2 → NP_081148.1  ubiquitin-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081148.1

    Status: VALIDATED

    Source sequence(s)
    AL807823
    Consensus CDS
    CCDS18058.1
    UniProtKB/Swiss-Prot
    Q812D6, Q91VX2, Q99K40
    UniProtKB/TrEMBL
    A2AMY5
    Related
    ENSMUSP00000030143.7, ENSMUST00000030143.13
    Conserved Domains (2) summary
    cd14277
    Location:53 → 90
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512 → 541
    DUF3697; Ubiquitin-associated protein 2

RNA

  1. NR_185031.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL807823

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41194313..41276016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538224.2 → XP_006538287.1  ubiquitin-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006538287.1

    UniProtKB/Swiss-Prot
    Q812D6, Q91VX2, Q99K40
    UniProtKB/TrEMBL
    A2AMY5
    Conserved Domains (2) summary
    cd14277
    Location:53 → 90
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:512 → 541
    DUF3697; Ubiquitin-associated protein 2

  2. XM_006538225.5 → XP_006538288.1  ubiquitin-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A2AMY5
    Conserved Domains (2) summary
    cd14277
    Location:59 → 96
    UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
    pfam12478
    Location:518 → 547
    DUF3697; Ubiquitin-associated protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VX2.1 GenPept UniProtKB/Swiss-Prot:Q91VX2

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