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Ncbp2 nuclear cap binding protein subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689116, updated on 18-Sep-2024

Summary

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Symbol
Ncbp2provided by RGD
Full Name
nuclear cap binding protein subunit 2provided by RGD
Primary source
RGD:1596188
See related
AllianceGenome:RGD:1596188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pigz; CBP20
Summary
Enables RNA 7-methylguanosine cap binding activity. Predicted to be involved in several processes, including mRNA metabolic process; positive regulation of mRNA 3'-end processing; and snRNA export from nucleus. Located in nucleus. Part of nuclear cap binding activity complex. Orthologous to human NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 232.2), Thymus (RPKM 223.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncbp2 in Genome Data Viewer
Location:
11q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82326002..82334839, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68821026..68829863, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72071838..72103087, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene SUMO specific peptidase 5 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene uncharacterized LOC108352349 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Z

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. Visa N, et al. J Cell Biol, 1996 Apr. PMID 8601613, Free PMC Article
  2. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Ishigaki Y, et al. Cell, 2001 Sep 7. PMID 11551508
  3. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Calero G, et al. Nat Struct Biol, 2002 Dec. PMID 12434151
  4. Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Matsuda D, et al. Nat Struct Mol Biol, 2007 Oct. PMID 17873884
  5. DcpS scavenger decapping enzyme can modulate pre-mRNA splicing. Shen V, et al. RNA, 2008 Jun. PMID 18426921, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA 7-methylguanosine cap binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA 7-methylguanosine cap binding ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables snRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables snRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in histone mRNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histone mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA cap binding complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear cap binding complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear cap binding complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear cap binding complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear cap-binding protein subunit 2
Names
20 kDa nuclear cap-binding protein
NCBP 20 kDa subunit
nuclear cap-binding protein subunit 2-like
phosphatidylinositol glycan anchor biosynthesis, class Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109525.1 → NP_001102995.1  nuclear cap-binding protein subunit 2

    See identical proteins and their annotated locations for NP_001102995.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473967
    UniProtKB/Swiss-Prot
    B1WC40
    UniProtKB/TrEMBL
    A6IRU8, A6IRU9
    Conserved Domains (1) summary
    cd12240
    Location:42 → 119
    RRM_NCBP2; RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    82326002..82334839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WC40.1 GenPept UniProtKB/Swiss-Prot:B1WC40

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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