Kctd7 potassium channel tetramerization domain containing 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kctd7provided by RGD
Official Full Name: potassium channel tetramerization domain containing 7provided by RGD
Primary source: RGD:1582914
See related: EnsemblRapid:ENSRNOG00000042384 AllianceGenome:RGD:1582914
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including intracellular glutamate homeostasis; intracellular potassium ion homeostasis; and membrane hyperpolarization. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 3. Orthologous to human KCTD7 (potassium channel tetramerization domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 74.9), Brain (RPKM 45.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32157141..32168463, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26520969..26532327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30024080..30033357, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH135160 (e-PCR)
- UniSTS:218437

RH137475 (e-PCR)
- UniSTS:219563

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular glutamate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transporter activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transporter activity	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD7

Names: potassium channel tetramerisation domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128194.2 → NP_001121666.1 BTB/POZ domain-containing protein KCTD7

See identical proteins and their annotated locations for NP_001121666.1

Status: PROVISIONAL

Source sequence(s)

BC162055

UniProtKB/Swiss-Prot

B1WC97

UniProtKB/TrEMBL

A0A8I6G9F0

Related

ENSRNOP00000001198.3, ENSRNOT00000001198.6

Conserved Domains (1) summary

cd18366
Location:48 → 139

BTB_POZ_KCTD7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7)