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Dda1 DET1 and DDB1 associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688813, updated on 2-Nov-2024

Summary

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Official Symbol
Dda1provided by RGD
Official Full Name
DET1 and DDB1 associated 1provided by RGD
Primary source
RGD:1584153
See related
EnsemblRapid:ENSRNOG00000039417 AllianceGenome:RGD:1584153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DDA1 (DET1 and DDB1 associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 49.5), Adrenal (RPKM 43.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dda1 in Genome Data Viewer
Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18190280..18197914)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18156310..18163938)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19877873..19885501)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene anoctamin 8 Neighboring gene GTP binding protein 3 Neighboring gene uncharacterized LOC134482466 Neighboring gene plasmalemma vesicle associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Faust TB, et al. Nat Chem Biol, 2020 Jan. PMID 31686031, Free PMC Article
  2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
  3. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Han T, et al. Science, 2017 Apr 28. PMID 28302793
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DET1- and DDB1-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134790.1 → NP_001128262.1  DET1- and DDB1-associated protein 1

    See identical proteins and their annotated locations for NP_001128262.1

    Status: VALIDATED

    Source sequence(s)
    BF549138, BF560086, BI289501, DY312023, DY472257
    UniProtKB/TrEMBL
    A6K9U2
    Conserved Domains (1) summary
    pfam10172
    Location:3 → 65
    DDA1; Det1 complexing ubiquitin ligase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18190280..18197914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275741.1 → XP_063131811.1  DET1- and DDB1-associated protein 1 isoform X3

  2. XM_017600246.1 → XP_017455735.1  DET1- and DDB1-associated protein 1 isoform X2

  3. XM_063275740.1 → XP_063131810.1  DET1- and DDB1-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0C8
    Related
    ENSRNOP00000104685.1, ENSRNOT00000134874.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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