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Elp4 elongator acetyltransferase complex subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 687694, updated on 14-Nov-2024

Summary

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Official Symbol
Elp4provided by RGD
Official Full Name
elongator acetyltransferase complex subunit 4provided by RGD
Primary source
RGD:1566052
See related
EnsemblRapid:ENSRNOG00000004787 AllianceGenome:RGD:1566052
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566052
Summary
Predicted to enable phosphorylase kinase regulator activity. Predicted to contribute to RNA polymerase II complex binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of elongator holoenzyme complex and transcription elongation factor complex. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 52.2), Thymus (RPKM 46.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elp4 in Genome Data Viewer
Location:
3q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (112617020..112839963, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (92162271..92385251, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (95733810..95954987, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 7 Neighboring gene reticulocalbin 1 Neighboring gene paired box 6 Neighboring gene ribosomal protein L35A like 6 Neighboring gene uncharacterized LOC120101618 Neighboring gene U2 spliceosomal RNA Neighboring gene inner mitochondrial membrane peptidase subunit 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and characterization of the human elongator complex. Hawkes NA, et al. J Biol Chem, 2002 Jan 25. PMID 11714725
  2. Human Elongator facilitates RNA polymerase II transcription through chromatin. Kim JH, et al. Proc Natl Acad Sci U S A, 2002 Feb 5. PMID 11818576, Free PMC Article
  3. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Close P, et al. J Biol Chem, 2012 Sep 21. PMID 22854966, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphorylase kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
elongator complex protein 4
Names
elongation protein 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115047.2 → NP_001108519.1  elongator complex protein 4

    See identical proteins and their annotated locations for NP_001108519.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158667
    UniProtKB/TrEMBL
    A0A8I6A5H6, B0BN35
    Conserved Domains (1) summary
    pfam05625
    Location:28 → 404
    PAXNEB; PAXNEB protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    112617020..112839963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105869.2 → XP_038961797.1  elongator complex protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5H6, F1M086
    Related
    ENSRNOP00000006385.8, ENSRNOT00000006385.9
    Conserved Domains (1) summary
    pfam05625
    Location:44 → 423
    PAXNEB; PAXNEB protein

  2. XM_039105870.2 → XP_038961798.1  elongator complex protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A5H6
    Conserved Domains (1) summary
    pfam05625
    Location:44 → 381
    PAXNEB; PAXNEB protein

  3. XM_063284571.1 → XP_063140641.1  elongator complex protein 4 isoform X4

    Related
    ENSRNOP00000087949.2, ENSRNOT00000097695.2

  4. XM_063284570.1 → XP_063140640.1  elongator complex protein 4 isoform X2

    Related
    ENSRNOP00000103642.1, ENSRNOT00000148973.1

  5. XM_039105871.2 → XP_038961799.1  elongator complex protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A5H6
    Conserved Domains (1) summary
    pfam05625
    Location:44 → 380
    PAXNEB; PAXNEB protein

RNA

  1. XR_005501986.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials