TADA2A transcriptional adaptor 2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: TADA2Aprovided by HGNC
Official Full Name: transcriptional adaptor 2Aprovided by HGNC
Primary source: HGNC:HGNC:11531
See related: Ensembl:ENSG00000276234 MIM:602276; AllianceGenome:HGNC:11531
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADA2; ADA2A; KL04P; hADA2; TADA2L
Summary: Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Annotation information: Note: ADA2 is an official symbol GeneID: 51816 and an alias on GeneID: 687. GeneID: 6871 is frequently referred to as ADA2 in the literature, and publications belonging to GeneID:51816 are sometimes mis-associated with GeneID: 6871 [06 Jul 2018]
Expression: Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (37406886..37479725)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (38397046..38466403)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (35766977..35839830)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel ADA2 Variants in a Romanian Case Series of DADA2.
Title: Novel ADA2 Variants in a Romanian Case Series of DADA2.
CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells.
Title: CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells.
ADA2 Deficiency Mimicking Acute Disseminated Encephalomyelitis.
Title: ADA2 Deficiency Mimicking Acute Disseminated Encephalomyelitis.
Circular RNA TADA2A promotes proliferation and migration via modulating of miR638/KIAA0101 signal in nonsmall cell lung cancer.
Title: Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer.
results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes
Title: Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.
Single nucleotide polymorphism in ADA2 gene is associated with type 1 diabetes.
Title: Genetic factors adaptive in a malarial environment may increase the risk of type 1 diabetes.
CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression.
Title: CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.
Observational study of gene-disease association. (HuGE Navigator)
Title: Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes.
Title: hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin.
The three-dimensional solution structure of the SWIRM domain from the human transcriptional adaptor ADA2alpha was reported.
Title: Structure and chromosomal DNA binding of the SWIRM domain.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93734 (e-PCR)
- UniSTS:89418

G58932 (e-PCR)
- UniSTS:136108

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in regulation of tubulin deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional adapter 2-alpha

Names: ADA2-like protein; transcriptional adaptor 2 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166105.3 → NP_001159577.2 transcriptional adapter 2-alpha isoform a

See identical proteins and their annotated locations for NP_001159577.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AC243654, AK225918, BC011753, DA244842

Consensus CDS

CCDS11319.1

UniProtKB/TrEMBL

A0A024R0U3, A0A024R0Y4

Related

ENSP00000481091.1, ENST00000615182.5

Conserved Domains (1) summary

COG5114
Location:28 → 440

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_001291918.2 → NP_001278847.1 transcriptional adapter 2-alpha isoform b

See identical proteins and their annotated locations for NP_001278847.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).

Source sequence(s)

AC243654, BC001172, DA244842

Consensus CDS

CCDS45656.1

UniProtKB/TrEMBL

A0A087WWR4

Related

ENSP00000480446.1, ENST00000620367.4

Conserved Domains (1) summary

COG5114
Location:28 → 272

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_001488.5 → NP_001479.4 transcriptional adapter 2-alpha isoform a

See identical proteins and their annotated locations for NP_001479.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the predominant transcript and encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AC243654, AK022767, BC011753

Consensus CDS

CCDS11319.1

UniProtKB/TrEMBL

A0A024R0U3, A0A024R0Y4

Related

ENSP00000477709.1, ENST00000612272.4

Conserved Domains (1) summary

COG5114
Location:28 → 440

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
NM_133439.4 → NP_597683.3 transcriptional adapter 2-alpha isoform b

See identical proteins and their annotated locations for NP_597683.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).

Source sequence(s)

AC243654, AK022767, BC001172

Consensus CDS

CCDS45656.1

UniProtKB/TrEMBL

A0A087WWR4

Conserved Domains (1) summary

COG5114
Location:28 → 272

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

37406886..37479725

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024982.1 → XP_016880471.1 transcriptional adapter 2-alpha isoform X3

Conserved Domains (1) summary

COG5114
Location:28 → 386

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_017024981.2 → XP_016880470.1 transcriptional adapter 2-alpha isoform X2

Conserved Domains (1) summary

COG5114
Location:28 → 420

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_047436612.1 → XP_047292568.1 transcriptional adapter 2-alpha isoform X3

Conserved Domains (1) summary

COG5114
Location:28 → 386

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_047436610.1 → XP_047292566.1 transcriptional adapter 2-alpha isoform X2
XM_011525154.3 → XP_011523456.1 transcriptional adapter 2-alpha isoform X4

See identical proteins and their annotated locations for XP_011523456.1

Conserved Domains (1) summary

COG5114
Location:2 → 377

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_047436613.1 → XP_047292569.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13
XM_047436609.1 → XP_047292565.1 transcriptional adapter 2-alpha isoform X1

UniProtKB/TrEMBL

A0A024R0U3, A0A024R0Y4
XM_017024985.2 → XP_016880474.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13

Conserved Domains (2) summary

COG5114
Location:3 → 339

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

pfam04433
Location:273 → 339

SWIRM; SWIRM domain
XM_017024983.2 → XP_016880472.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13

Conserved Domains (2) summary

COG5114
Location:3 → 339

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

pfam04433
Location:273 → 339

SWIRM; SWIRM domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

1646042..1718895

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329314.1 → XP_054185289.1 transcriptional adapter 2-alpha isoform X3
XM_054329313.1 → XP_054185288.1 transcriptional adapter 2-alpha isoform X2
XM_054329317.1 → XP_054185292.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13
XM_054329315.1 → XP_054185290.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13
XM_054329316.1 → XP_054185291.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

38397046..38466403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054317020.1 → XP_054172995.1 transcriptional adapter 2-alpha isoform X3
XM_054317018.1 → XP_054172993.1 transcriptional adapter 2-alpha isoform X2
XM_054317016.1 → XP_054172991.1 transcriptional adapter 2-alpha isoform X1

UniProtKB/Swiss-Prot

A8MVD0, B3KMU9, O75478, Q9BVJ0, Q9UCW2, Q9UP49

UniProtKB/TrEMBL

A0A0S2Z4G1
XM_054317019.1 → XP_054172994.1 transcriptional adapter 2-alpha isoform X3
XM_054317017.1 → XP_054172992.1 transcriptional adapter 2-alpha isoform X2
XM_054317021.1 → XP_054172996.1 transcriptional adapter 2-alpha isoform X4
XM_054317024.1 → XP_054172999.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13
XM_054317022.1 → XP_054172997.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13
XM_054317023.1 → XP_054172998.1 transcriptional adapter 2-alpha isoform X5

UniProtKB/TrEMBL

B3KU13