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Gtf2f2 general transcription factor IIF, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 68705, updated on 28-Oct-2024

Summary

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Official Symbol
Gtf2f2provided by MGI
Official Full Name
general transcription factor IIF, polypeptide 2provided by MGI
Primary source
MGI:MGI:1915955
See related
Ensembl:ENSMUSG00000067995 AllianceGenome:MGI:1915955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TFIIF-beta; 1110031C13Rik
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be part of transcription factor TFIIF complex and transcription factor TFIIH holo complex. Is expressed in genitourinary system. Orthologous to human GTF2F2 (general transcription factor IIF subunit 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), placenta adult (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gtf2f2 in Genome Data Viewer
Location:
14 D3; 14 40.29 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76134368..76248356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75896928..76010865, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37150 Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene tumor protein, translationally-controlled 1 Neighboring gene STARR-positive B cell enhancer ABC_E10835 Neighboring gene predicted gene, 52138 Neighboring gene STARR-seq mESC enhancer starr_37153 Neighboring gene armadillo repeat containing 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37154 Neighboring gene potassium channel tetramerisation domain containing 4 Neighboring gene predicted gene, 53845 Neighboring gene predicted gene, 25517 Neighboring gene STARR-seq mESC enhancer starr_37156 Neighboring gene predicted gene, 36429 Neighboring gene predicted gene, 36477 Neighboring gene STARR-seq mESC enhancer starr_37162 Neighboring gene STARR-seq mESC enhancer starr_37163 Neighboring gene STARR-seq mESC enhancer starr_37165 Neighboring gene GPALPP motifs containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain. Wagner SD, et al. Mol Cell Biol, 2010 Jan. PMID 19841064, Free PMC Article
  2. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Hsu LC, et al. Mol Cell Biol, 2003 Dec. PMID 14612417, Free PMC Article
  3. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
  4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIF complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor IIF subunit 2
Names
ATP-dependent helicase GTF2F2
transcription initiation factor IIF subunit beta
NP_001405473.1
NP_001405474.1
NP_081092.1
XP_030103845.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418544.1 → NP_001405473.1  general transcription factor IIF subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122192, AC140244

  2. NM_001418545.1 → NP_001405474.1  general transcription factor IIF subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122192, AC140244

  3. NM_026816.4 → NP_081092.1  general transcription factor IIF subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_081092.1

    Status: VALIDATED

    Source sequence(s)
    AC122192, AC140244
    Consensus CDS
    CCDS36981.1
    UniProtKB/Swiss-Prot
    Q8R0A0
    UniProtKB/TrEMBL
    Q3UMJ4
    Related
    ENSMUSP00000086312.5, ENSMUST00000088922.5
    Conserved Domains (1) summary
    pfam02270
    Location:13 → 236
    TFIIF_beta; Transcription initiation factor IIF, beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    76134368..76248356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247985.1 → XP_030103845.1  general transcription factor IIF subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam02270
    Location:52 → 116
    TFIIF_beta; Transcription initiation factor IIF, beta subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0A0.1 GenPept UniProtKB/Swiss-Prot:Q8R0A0

Gene LinkOut

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