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Xpnpep3 X-prolyl aminopeptidase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685823, updated on 10-Oct-2024

Summary

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Official Symbol
Xpnpep3provided by RGD
Official Full Name
X-prolyl aminopeptidase 3provided by RGD
Primary source
RGD:1589063
See related
EnsemblRapid:ENSRNOG00000019196 AllianceGenome:RGD:1589063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
APP3
Summary
Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within glomerular filtration and protein processing. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 64.7), Heart (RPKM 60.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Xpnpep3 in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114806398..114858934)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112926154..112978793)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122636252..122686983)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 17 Neighboring gene uncharacterized LOC134479943 Neighboring gene ST13, Hsp70 interacting protein Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene ribosomal protein L37A, pseudogene 2 Neighboring gene transfer RNA proline (anticodon AGG) 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes. Singh R, et al. J Biol Chem, 2017 Jun 16. PMID 28476889, Free PMC Article
  2. Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2. Inoue M, et al. J Cell Sci, 2015 Feb 15. PMID 25609706
  3. Processing of mitochondrial presequences. Mossmann D, et al. Biochim Biophys Acta, 2012 Sep-Oct. PMID 22172993
  4. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. O'Toole JF, et al. J Clin Invest, 2010 Mar. PMID 20179356, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188876

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in glomerular filtration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glomerular filtration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
xaa-Pro aminopeptidase 3
Names
X-Pro aminopeptidase 3
X-prolyl aminopeptidase 3, mitochondrial
aminopeptidase P3
probable Xaa-Pro aminopeptidase 3
NP_001124054.3
XP_006242183.1
XP_038935832.1
XP_038935833.1
XP_063120333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130582.3 → NP_001124054.3  xaa-Pro aminopeptidase 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    B5DEQ3
    UniProtKB/TrEMBL
    A0A8I6GA16, A6HSZ7
    Related
    ENSRNOP00000082871.2, ENSRNOT00000111293.2
    Conserved Domains (2) summary
    smart01011
    Location:67 → 206
    AMP_N; Aminopeptidase P, N-terminal domain
    cd01087
    Location:252 → 489
    Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    114806398..114858934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264263.1 → XP_063120333.1  xaa-Pro aminopeptidase 3 isoform X1

  2. XM_006242121.5 → XP_006242183.1  xaa-Pro aminopeptidase 3 isoform X2

    See identical proteins and their annotated locations for XP_006242183.1

    UniProtKB/Swiss-Prot
    B5DEQ3
    UniProtKB/TrEMBL
    A6HSZ9
    Conserved Domains (2) summary
    smart01011
    Location:15 → 127
    AMP_N; Aminopeptidase P, N-terminal domain
    cd01087
    Location:173 → 410
    Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

  3. XM_039079904.2 → XP_038935832.1  xaa-Pro aminopeptidase 3 isoform X2

    UniProtKB/Swiss-Prot
    B5DEQ3
    UniProtKB/TrEMBL
    A6HSZ9
    Conserved Domains (2) summary
    smart01011
    Location:15 → 127
    AMP_N; Aminopeptidase P, N-terminal domain
    cd01087
    Location:173 → 410
    Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

  4. XM_039079905.2 → XP_038935833.1  xaa-Pro aminopeptidase 3 isoform X3

    Conserved Domains (1) summary
    cd01087
    Location:1 → 235
    Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DEQ3.1 GenPept UniProtKB/Swiss-Prot:B5DEQ3

Gene LinkOut

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