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Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [ Mus musculus (house mouse) ]

Gene ID: 68576, updated on 18-Sep-2024

Summary

Official Symbol
Lamtor5provided by MGI
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5provided by MGI
Primary source
MGI:MGI:1915826
See related
Ensembl:ENSMUSG00000087260 AllianceGenome:MGI:1915826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XIP; Hbxip; 1110003H18Rik
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of interleukin-8 production; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol. Predicted to be part of Ragulator complex. Predicted to be active in lysosome. Orthologous to human LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 71.3), large intestine adult (RPKM 37.1) and 28 other tissues See more
Orthologs
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Genomic context

See Lamtor5 in Genome Data Viewer
Location:
3 F2.3; 3 46.79 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107186174..107191398)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107278858..107284082)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chymosin Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene prokineticin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:107081789-107082089 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 4 Neighboring gene RNA binding motif protein 15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107136515-107136698 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in TORC1 signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell size ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ragulator complex protein LAMTOR5
Names
HBV X-interacting protein homolog
HBX-interacting protein homolog
hepatitis B virus X-interacting protein homolog
hepatitis B virus x interacting protein
late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026774.2NP_081050.2  ragulator complex protein LAMTOR5

    See identical proteins and their annotated locations for NP_081050.2

    Status: VALIDATED

    Source sequence(s)
    AI552736, BC028547
    Consensus CDS
    CCDS51042.1
    UniProtKB/TrEMBL
    G3UW70
    Related
    ENSMUSP00000129012.2, ENSMUST00000145735.6
    Conserved Domains (1) summary
    pfam16672
    Location:55142
    LAMTOR5; Ragulator complex protein LAMTOR5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107186174..107191398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)