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Caly calcyon neuron-specific vesicular protein [ Mus musculus (house mouse) ]

Gene ID: 68566, updated on 2-Nov-2024

Summary

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Official Symbol
Calyprovided by MGI
Official Full Name
calcyon neuron-specific vesicular proteinprovided by MGI
Primary source
MGI:MGI:1915816
See related
Ensembl:ENSMUSG00000025468 AllianceGenome:MGI:1915816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drd1ip; Calcyon; 0710001P07Rik; 1110004A22Rik
Summary
Predicted to enable clathrin light chain binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse. Is expressed in central nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human CALY (calcyon neuron specific vesicular protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 66.1), CNS E18 (RPKM 58.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Caly in Genome Data Viewer
Location:
7 F4; 7 85.07 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139649793..139662485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140069880..140082571, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tubulin, gamma complex component 2 Neighboring gene STARR-positive B cell enhancer ABC_E6615 Neighboring gene STARR-positive B cell enhancer ABC_E8219 Neighboring gene zinc finger protein 511 Neighboring gene VISTA enhancer mm1489 Neighboring gene msh homeobox 3 Neighboring gene STARR-seq mESC enhancer starr_20446 Neighboring gene STARR-seq mESC enhancer starr_20447 Neighboring gene proline-rich acidic protein 1 Neighboring gene fucose mutarotase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood. Vazdarjanova A, et al. Mol Psychiatry, 2011 Jun. PMID 21403673, Free PMC Article
  2. Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Trantham-Davidson H, et al. Behav Brain Res, 2008 Jun 3. PMID 18295356, Free PMC Article
  3. Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain. Elmarakby A, et al. PLoS One, 2019. PMID 30753204, Free PMC Article
  4. Structure and expression of the murine calcyon gene. Dai R, et al. Gene, 2003 Jun 5. PMID 12853145
  5. Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon. Shi L, et al. Int J Biochem Cell Biol, 2017 Sep. PMID 28734834, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that upregulation of calcyon in forebrain could increase BP via alterations in noradrenergic transmission and increased oxidative stress during high salt challenge.
    Title: Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.
  2. endocytic and cargo sorting functions of Caly in neurons
    Title: Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon.
  3. The data of this study suggested that calcyon directly interacts with mu3A and mu3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes.
    Title: Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.
  4. The resultd of this study showed that with calcyon-overexpressing Cal(OE) transgenic mice that lifelong calcyon upregulation impairs executive functions including response inhibition and working memory.
    Title: Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood.
  5. Taken together, the present studies involving biochemical, immunological and electrophysiological analyses raise the possibility that calcyon plays a specialized role in regulating activity-dependent removal of synaptic AMPARs.
    Title: Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus.
  6. Transgenic mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output.
    Title: Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin light chain binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin light chain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport IEA
Inferred from Electronic Annotation
more info
  
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of retrograde axon cargo transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of retrograde axon cargo transport ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic endocytic zone IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic endocytic zone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuron-specific vesicular protein calcyon
Names
calcyon; D1 dopamine receptor-interacting protein
dopamine receptor D1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190385.1 → NP_001177314.1  neuron-specific vesicular protein calcyon

    See identical proteins and their annotated locations for NP_001177314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 3' UTR compared to variant A, and is also known as mcal-B. Variants A, B and C encode the same protein.
    Source sequence(s)
    AK002979, AK003400
    Consensus CDS
    CCDS21962.1
    UniProtKB/Swiss-Prot
    Q9D1K9, Q9DCA7
    Related
    ENSMUSP00000026541.8, ENSMUST00000026541.15
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 182
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  2. NM_001190386.1 → NP_001177315.1  neuron-specific vesicular protein calcyon

    See identical proteins and their annotated locations for NP_001177315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR compared to variant A. Variants A, B and C encode the same protein.
    Source sequence(s)
    AC109205
    Consensus CDS
    CCDS21962.1
    UniProtKB/Swiss-Prot
    Q9D1K9, Q9DCA7
    Related
    ENSMUSP00000130779.3, ENSMUST00000166758.4
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 182
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  3. NM_026769.5 → NP_081045.2  neuron-specific vesicular protein calcyon

    See identical proteins and their annotated locations for NP_081045.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the shortest transcript, and is also known as mcal-A. Variants A, B and C encode the same protein.
    Source sequence(s)
    AC109205, AK002979, AK003400
    Consensus CDS
    CCDS21962.1
    UniProtKB/Swiss-Prot
    Q9D1K9, Q9DCA7
    Related
    ENSMUSP00000148173.2, ENSMUST00000211283.2
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 182
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139649793..139662485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536235.5 → XP_006536298.1  neuron-specific vesicular protein calcyon isoform X1

    See identical proteins and their annotated locations for XP_006536298.1

    Conserved Domains (1) summary
    pfam06387
    Location:12 → 193
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  2. XM_011249853.4 → XP_011248155.1  neuron-specific vesicular protein calcyon isoform X2

    See identical proteins and their annotated locations for XP_011248155.1

    UniProtKB/Swiss-Prot
    Q9D1K9, Q9DCA7
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 182
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  3. XM_006536237.3 → XP_006536300.1  neuron-specific vesicular protein calcyon isoform X2

    See identical proteins and their annotated locations for XP_006536300.1

    UniProtKB/Swiss-Prot
    Q9D1K9, Q9DCA7
    Related
    ENSMUSP00000148159.2, ENSMUST00000211044.2
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 182
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  4. XM_006536236.4 → XP_006536299.1  neuron-specific vesicular protein calcyon isoform X1

    See identical proteins and their annotated locations for XP_006536299.1

    Conserved Domains (1) summary
    pfam06387
    Location:12 → 193
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCA7.1 GenPept UniProtKB/Swiss-Prot:Q9DCA7

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