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Pdrg1 p53 and DNA damage regulated 1 [ Mus musculus (house mouse) ]

Gene ID: 68559, updated on 2-Nov-2024

Summary

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Official Symbol
Pdrg1provided by MGI
Official Full Name
p53 and DNA damage regulated 1provided by MGI
Primary source
MGI:MGI:1915809
See related
Ensembl:ENSMUSG00000027472 AllianceGenome:MGI:1915809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdrg; 1110004D19Rik
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human PDRG1 (p53 and DNA damage regulated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 53.3), heart adult (RPKM 47.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pdrg1 in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152850810..152857939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153008890..153016019, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06085 Neighboring gene dual specificity phosphatase-like 15 Neighboring gene tubulin tyrosine ligase-like family, member 9 Neighboring gene STARR-seq mESC enhancer starr_06086 Neighboring gene predicted gene 14199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152840956-152841257 Neighboring gene X-linked Kx blood group related 7 Neighboring gene predicted gene, 32286 Neighboring gene cerebral cavernous malformation 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. Luo X, et al. Oncogene, 2003 Oct 16. PMID 14562055
  2. Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. Lin L, et al. Neuron, 2024 Jul 3. PMID 38697111,
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation
    Title: Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
p53 and DNA damage-regulated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418641.1 → NP_001405570.1  p53 and DNA damage-regulated protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL928862

  2. NM_001418642.1 → NP_001405571.1  p53 and DNA damage-regulated protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928862

  3. NM_001418643.1 → NP_001405572.1  p53 and DNA damage-regulated protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928862

  4. NM_001418644.1 → NP_001405573.1  p53 and DNA damage-regulated protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928862

  5. NM_001418645.1 → NP_001405574.1  p53 and DNA damage-regulated protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928862

  6. NM_001418646.1 → NP_001405575.1  p53 and DNA damage-regulated protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928862

  7. NM_178939.3 → NP_849270.1  p53 and DNA damage-regulated protein 1 isoform a

    See identical proteins and their annotated locations for NP_849270.1

    Status: VALIDATED

    Source sequence(s)
    AL928862
    Consensus CDS
    CCDS16904.1
    UniProtKB/Swiss-Prot
    P59048
    UniProtKB/TrEMBL
    Q3UKN2
    Related
    ENSMUSP00000028972.9, ENSMUST00000028972.9
    Conserved Domains (1) summary
    cl09111
    Location:27 → 108
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152850810..152857939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252038.1 → XP_030107898.1  p53 and DNA damage-regulated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P59048
    UniProtKB/TrEMBL
    Q3UKN2
    Conserved Domains (1) summary
    cl09111
    Location:27 → 108
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59048.1 GenPept UniProtKB/Swiss-Prot:P59048

Gene LinkOut

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