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Smim14 small integral membrane protein 14 [ Mus musculus (house mouse) ]

Gene ID: 68552, updated on 2-Nov-2024

Summary

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Official Symbol
Smim14provided by MGI
Official Full Name
small integral membrane protein 14provided by MGI
Primary source
MGI:MGI:1915802
See related
Ensembl:ENSMUSG00000037822 AllianceGenome:MGI:1915802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAd4; 1110003E01Rik; 1700127H04Rik; 5430439C17Rik
Summary
Acts upstream of or within blastocyst hatching. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including bone; central nervous system; definitive endoderm; early conceptus; and secondary oocyte. Orthologous to human SMIM14 (small integral membrane protein 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 25.8), genital fat pad adult (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Smim14 in Genome Data Viewer
Location:
5 C3.1; 5 33.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65604187..65694492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65446844..65537149, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3577 Neighboring gene VISTA enhancer mm1569 Neighboring gene lipoic acid synthetase Neighboring gene STARR-seq mESC enhancer starr_13263 Neighboring gene STARR-positive B cell enhancer ABC_E4757 Neighboring gene UDP-glucose dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E4758 Neighboring gene STARR-seq mESC enhancer starr_13264 Neighboring gene STARR-positive B cell enhancer ABC_E4759 Neighboring gene STARR-positive B cell enhancer ABC_E8059 Neighboring gene STARR-positive B cell enhancer ABC_E11290 Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene PDS5 cohesin associated factor A Neighboring gene predicted gene, 24399

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm. Gonçalves L, et al. Int J Dev Biol, 2011. PMID 21553379
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC7185

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small integral membrane protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376971.1 → NP_001363900.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  2. NM_001376972.1 → NP_001363901.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  3. NM_001376973.1 → NP_001363902.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Related
    ENSMUSP00000113456.2, ENSMUST00000121661.8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  4. NM_001376974.1 → NP_001363903.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  5. NM_001376975.1 → NP_001363904.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  6. NM_001376976.1 → NP_001363905.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  7. NM_001376977.1 → NP_001363906.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  8. NM_001376978.1 → NP_001363907.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  9. NM_001376979.1 → NP_001363908.1  small integral membrane protein 14

    Status: VALIDATED

    Source sequence(s)
    AC136513
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  10. NM_133697.4 → NP_598458.1  small integral membrane protein 14

    See identical proteins and their annotated locations for NP_598458.1

    Status: VALIDATED

    Source sequence(s)
    AC136513, AK164394, CJ052807
    Consensus CDS
    CCDS19309.1
    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Related
    ENSMUSP00000122363.2, ENSMUST00000139122.8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65604187..65694492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165458.1 → XP_036021351.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q91VT8
    UniProtKB/TrEMBL
    F8WHW8
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VT8.1 GenPept UniProtKB/Swiss-Prot:Q91VT8

Gene LinkOut

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