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Tefm transcription elongation factor, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 68550, updated on 28-Oct-2024

Summary

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Official Symbol
Tefmprovided by MGI
Official Full Name
transcription elongation factor, mitochondrialprovided by MGI
Primary source
MGI:MGI:1915800
See related
Ensembl:ENSMUSG00000046909 AllianceGenome:MGI:1915800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110002N22Rik
Summary
Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription and oxidative phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 3.7), CNS E11.5 (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tefm in Genome Data Viewer
Location:
11 B5; 11 47.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80027500..80033697, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80136674..80142871, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor-like factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79881110-79881263 Neighboring gene STARR-seq mESC enhancer starr_30136 Neighboring gene ATPase family, AAA domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_30137 Neighboring gene STARR-seq mESC enhancer starr_30138 Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene ArfGAP with dual PH domains 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30143 Neighboring gene STARR-positive B cell enhancer ABC_E7025 Neighboring gene ring finger protein 135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TEFM regulates both transcription elongation and RNA processing in mitochondria. Jiang S, et al. EMBO Rep, 2019 Jun. PMID 31036713, Free PMC Article
  2. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Jenne DE, et al. Genes Chromosomes Cancer, 2003 Jun. PMID 12696059
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ22729

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA polymerase processivity factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA polymerase processivity factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in oxidative phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription elongation by mitochondrial RNA polymerase IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transcription elongation factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183275.2 → NP_899098.2  transcription elongation factor, mitochondrial

    See identical proteins and their annotated locations for NP_899098.2

    Status: VALIDATED

    Source sequence(s)
    AK146639, BE949440
    Consensus CDS
    CCDS36241.1
    UniProtKB/Swiss-Prot
    Q5SSK3
    Related
    ENSMUSP00000059304.10, ENSMUST00000050207.10
    Conserved Domains (1) summary
    cl22429
    Location:80 → 128
    HHH_5; Helix-hairpin-helix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80027500..80033697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249204.3 → XP_011247506.1  transcription elongation factor, mitochondrial isoform X1

    Conserved Domains (2) summary
    cl21482
    Location:192 → 375
    RuvC_like; Crossover junction endodeoxyribonuclease RuvC and similar proteins
    cl22429
    Location:80 → 128
    HHH_5; Helix-hairpin-helix domain

  2. XM_030246262.1 → XP_030102122.1  transcription elongation factor, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q8BTE4

  3. XM_011249205.1 → XP_011247507.1  transcription elongation factor, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011247507.1

    UniProtKB/TrEMBL
    Q8BTE4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SSK3.1 GenPept UniProtKB/Swiss-Prot:Q5SSK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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