U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sgo2a shugoshin 2A [ Mus musculus (house mouse) ]

Gene ID: 68549, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Sgo2aprovided by MGI
Official Full Name
shugoshin 2Aprovided by MGI
Primary source
MGI:MGI:1098767
See related
Ensembl:ENSMUSG00000026039 AllianceGenome:MGI:1098767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgol2; Sgol2a; Tripin; D1Ertd8e; 1110007N04Rik; 4932411A20Rik; 5730576N04Rik
Summary
Acts upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in kinetochore. Is expressed in nervous system and oocyte. Orthologous to human SGO2 (shugoshin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 4.8) and 12 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sgo2a in Genome Data Viewer
Location:
1 C1.3; 1 28.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58024499..58065436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57985340..58026277)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene potassium channel tetramerisation domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene aldehyde oxidase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. Tashiro S, et al. Nat Commun, 2016 Jan 25. PMID 26804021, Free PMC Article
  2. Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes. Rattani A, et al. Elife, 2013 Nov 5. PMID 24192037, Free PMC Article
  3. Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis. Gómez R, et al. EMBO Rep, 2007 Feb. PMID 17205076, Free PMC Article
  4. Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome. Faridi R, et al. Clin Genet, 2017 Feb. PMID 27629923, Free PMC Article
  5. Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis. Previato de Almeida L, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31019073, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. By promoting proteolysis of cyclins and Cdc25B at germinal vesicle stage, APC/C associated Cdh1(APC/CCdh1) delays increase in Cdk1 activity, leading to germinal vesicle breakdown (GVBD); by moderating the rate at which Cdk1 is activated following GVBD, APC/CCdh1 creates conditions necessary for the removal of shugoshin-2 from chromosome arms by Aurora B/C kinase, an event crucial for efficient resolution of chiasmata.
    Title: APC/C(Cdh1) Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.
  2. Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
    Title: Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
  3. In mouse, Sgol2a encoding shugoshin-like 2a is necessary during meiosis in both sexes to maintain the integrity of the cohesin complex that tethers sister chromatids. Human SGO2 has not previously been implicated in any disorder, but in this case of POI and perhaps others, it is a candidate for unexplained infertility.
    Title: Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome.
  4. Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body 'knob'.
    Title: Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
  5. Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E.
    Title: Sequential assembly of centromeric proteins in male mouse meiosis.
  6. SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres
    Title: Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice.
  7. Results show that shugoshin Sgo2 is expressed in germ cells.
    Title: Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of maintenance of meiotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic sister chromatid cohesion involved in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitotic cohesin complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
shugoshin 2
Names
sgo2
shugoshin-like 2
shugoshin-like 2a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177867.1 → NP_001171338.1  shugoshin 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC052742, CN716821
    UniProtKB/Swiss-Prot
    Q7TSY8
    Conserved Domains (1) summary
    pfam05539
    Location:35 → 228
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

  2. NM_199007.2 → NP_950172.1  shugoshin 2 isoform 1

    See identical proteins and their annotated locations for NP_950172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK042448, AK138621, BC052742
    Consensus CDS
    CCDS35574.1
    UniProtKB/Swiss-Prot
    Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55
    Related
    ENSMUSP00000027202.9, ENSMUST00000027202.9
    Conserved Domains (1) summary
    pfam05539
    Location:135 → 328
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58024499..58065436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSY8.1 GenPept UniProtKB/Swiss-Prot:Q7TSY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous