Tmem109 transmembrane protein 109 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem109provided by MGI
Official Full Name: transmembrane protein 109provided by MGI
Primary source: MGI:MGI:1915789
See related: Ensembl:ENSMUSG00000034659 AllianceGenome:MGI:1915789
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110006I15Rik
Summary: Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nuclear membrane and sarcoplasmic reticulum membrane. Predicted to be part of monoatomic ion channel complex. Is expressed in central nervous system; early conceptus; retina; and secondary oocyte. Orthologous to human TMEM109 (transmembrane protein 109). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 107.7), lung adult (RPKM 86.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 7.29 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10848021..10859107, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10870657..10881743, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ca[2+] storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 23.
Title: Ca(2+) storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 23.
Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23)
Title: Dysregulated Zn(2+) homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca(2+) leakage.
MG23 plays a protective role against UVC by accumulating alphaBC in the close vicinity of the ER
Title: Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
MG23 is an essential component of ER-generated lethal signals provoked upon DNA damage, specifying cell fate under pathophysiological conditions.
Title: Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA958958 (e-PCR)
- UniSTS:160795

Tmem109 (e-PCR), detects polymorphism
- UniSTS:498257

RH126209 (e-PCR)
- UniSTS:162917

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to gamma radiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated monoatomic cation channel TMEM109

Names: mg23; mitsugumin-23; mitsugumin23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.