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Atp8b2 ATPase phospholipid transporting 8B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685152, updated on 2-Nov-2024

Summary

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Official Symbol
Atp8b2provided by RGD
Official Full Name
ATPase phospholipid transporting 8B2provided by RGD
Primary source
RGD:1597731
See related
EnsemblRapid:ENSRNOG00000020822 AllianceGenome:RGD:1597731
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylcholine flippase activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to be located in Golgi apparatus; cytosol; and nucleolus. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane and trans-Golgi network. Orthologous to human ATP8B2 (ATPase phospholipid transporting 8B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 141.4), Thymus (RPKM 106.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp8b2 in Genome Data Viewer
Location:
2q34
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177676205..177699575, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175378514..175402265, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189285961..189306947, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Src homology 2 domain containing E Neighboring gene interleukin 6 receptor Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134485640 Neighboring gene aquaporin 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine flippase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase ID
Names
ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATPase, class I, type 8B, member 2
Probable phospholipid-transporting ATPase ID-like
NP_001403541.1
XP_001062555.3
XP_038959701.2
XP_038959702.1
XP_038959706.1
XP_063138614.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416612.1 → NP_001403541.1  phospholipid-transporting ATPase ID

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D4A509
    Related
    ENSRNOP00000028246.5, ENSRNOT00000028246.10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    177676205..177699575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103773.2 → XP_038959701.2  phospholipid-transporting ATPase ID isoform X2

    UniProtKB/TrEMBL
    D4A509

  2. XM_063282544.1 → XP_063138614.1  phospholipid-transporting ATPase ID isoform X2

    UniProtKB/TrEMBL
    D4A509

  3. XM_039103778.2 → XP_038959706.1  phospholipid-transporting ATPase ID isoform X2

    UniProtKB/TrEMBL
    A6J6I1, D4A509
    Conserved Domains (1) summary
    cd02073
    Location:31 → 972
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  4. XM_039103774.2 → XP_038959702.1  phospholipid-transporting ATPase ID isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJC6, A6J6I1
    Conserved Domains (1) summary
    cd02073
    Location:50 → 991
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  5. XM_001062555.7 → XP_001062555.3  phospholipid-transporting ATPase ID isoform X1

    See identical proteins and their annotated locations for XP_001062555.3

    UniProtKB/TrEMBL
    A0A8I6GJC6, A6J6I1
    Conserved Domains (1) summary
    cd02073
    Location:50 → 991
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
Nucleotide Protein Strain
Heading Accession and Version

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