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H2-Q8 histocompatibility 2, Q region locus 8 [ Mus musculus (house mouse) ]

Gene ID: 68395, updated on 17-Aug-2024

Summary

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Official Symbol
H2-Q8provided by MGI
Official Full Name
histocompatibility 2, Q region locus 8provided by MGI
Primary source
MGI:MGI:95937
See related
AllianceGenome:MGI:95937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qa8; Qa-2; Qa-8; H-2Q8; Ms10t; Gm53175; MMS10-T
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including Golgi apparatus; bounding membrane of organelle; and endoplasmic reticulum exit site. Predicted to be part of MHC class I peptide loading complex; MHC class I protein complex; and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in spleen. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See H2-Q8 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35737710..35742945)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene archain 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:35597630-35597931 Neighboring gene predicted gene, 54000 Neighboring gene histocompatibility 2, Q region locus 9 Neighboring gene predicted gene, 53263

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000083.7 Chromosome 17 Reference GRCm39 C57BL/6J

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and transcription of Qa-2-encoding genes in mouse lymphocytes and blastocysts. Cai W, et al. Immunogenetics, 1996. PMID 8952959
  2. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Weiss EH, et al. Nature, 1984 Aug 23-29. PMID 6088985
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
H-2 class I histocompatibility antigen, Q8 alpha chain
Names
histocompatibility 2, Q region locus 6-like
minisatellite 10t detected by probe MMS10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424319.1 → NP_001411248.1  H-2 class I histocompatibility antigen, Q8 alpha chain isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    CU467494
    UniProtKB/Swiss-Prot
    P14430
    UniProtKB/TrEMBL
    P79567

  2. NM_001424320.1 → NP_001411249.1  H-2 class I histocompatibility antigen, Q8 alpha chain isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    CU467494
    UniProtKB/Swiss-Prot
    P14430
    UniProtKB/TrEMBL
    P79567

  3. NM_001424322.1 → NP_001411251.1  H-2 class I histocompatibility antigen, Q8 alpha chain isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    CU467494
    UniProtKB/Swiss-Prot
    P14430

  4. NM_001424323.1 → NP_001411252.1  H-2 class I histocompatibility antigen, Q8 alpha chain isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    CU467494
    UniProtKB/Swiss-Prot
    P14430

  5. NM_001424324.1 → NP_001411253.1  H-2 class I histocompatibility antigen, Q8 alpha chain isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    CU467494
    UniProtKB/Swiss-Prot
    P14430

  6. NM_023124.6 → NP_075613.3  H-2 class I histocompatibility antigen, Q8 alpha chain isoform a precursor

    See identical proteins and their annotated locations for NP_075613.3

    Status: VALIDATED

    Source sequence(s)
    CU467494
    UniProtKB/Swiss-Prot
    P14430
    UniProtKB/TrEMBL
    P79567

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35737710..35742945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14430.1 GenPept UniProtKB/Swiss-Prot:P14430

Gene LinkOut

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