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Mia3 MIA SH3 domain ER export factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683007, updated on 14-Nov-2024

Summary

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Official Symbol
Mia3provided by RGD
Official Full Name
MIA SH3 domain ER export factor 3provided by RGD
Primary source
RGD:1591600
See related
EnsemblRapid:ENSRNOG00000059202 AllianceGenome:RGD:1591600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cargo receptor activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; cell migration involved in sprouting angiogenesis; and regulation of leukocyte migration. Predicted to act upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Predicted to be located in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 243.2), Heart (RPKM 213.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mia3 in Genome Data Viewer
Location:
13q26
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97502040..97547155, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94970421..95012071, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101727434..101770127, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096334 Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC120096335 Neighboring gene uncharacterized LOC108352586 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 4 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit A Neighboring gene uncharacterized LOC120096336 Neighboring gene HHIP like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TANGO is a tumor suppressor of malignant melanoma. Arndt S, et al. Int J Cancer, 2006 Dec 15. PMID 17044017
  2. Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate the migration of human monocytes. Arndt S, et al. J Leukoc Biol, 2007 Dec. PMID 17726152
  3. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. Santos AJ, et al. J Cell Biol, 2016 May 9. PMID 27138255, Free PMC Article
  4. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Saito K, et al. Mol Biol Cell, 2011 Jul 1. PMID 21525241, Free PMC Article
  5. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Saito K, et al. Cell, 2009 Mar 6. PMID 19269366

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chondrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoprotein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transport and Golgi organization protein 1 homolog
Names
MIA family member 3, ER export factor
melanoma inhibitory activity family, member 3
melanoma inhibitory activity protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398684.1 → NP_001385613.1  transport and Golgi organization protein 1 homolog isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JVM2
    Related
    ENSRNOP00000100877.1, ENSRNOT00000162162.1
    Conserved Domains (3) summary
    PHA03307
    Location:1665 → 1920
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR04523
    Location:1230 → 1615
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cl17036
    Location:38 → 109
    SH3; Src Homology 3 domain superfamily

  2. NM_001398698.2 → NP_001385627.1  transport and Golgi organization protein 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOP00000071370.3, ENSRNOT00000080170.3
    Conserved Domains (2) summary
    PHA03307
    Location:525 → 780
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:79 → 457
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    97502040..97547155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091493.2 → XP_038947421.1  transport and Golgi organization protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGK4
    Related
    ENSRNOP00000069539.3, ENSRNOT00000085600.3
    Conserved Domains (2) summary
    TIGR04523
    Location:1230 → 1615
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cl17036
    Location:38 → 109
    SH3; Src Homology 3 domain superfamily

  2. XM_063272603.1 → XP_063128673.1  transport and Golgi organization protein 1 homolog isoform X2

  3. XM_063272604.1 → XP_063128674.1  transport and Golgi organization protein 1 homolog isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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