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Matcap2 microtubule associated tyrosine carboxypeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 68283, updated on 2-Nov-2024

Summary

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Official Symbol
Matcap2provided by MGI
Official Full Name
microtubule associated tyrosine carboxypeptidase 2provided by MGI
Primary source
MGI:MGI:1915533
See related
Ensembl:ENSMUSG00000036411 AllianceGenome:MGI:1915533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0895; 1110003N12Rik; 9530077C05Rik
Summary
Predicted to enable carboxypeptidase activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including adrenal gland; central nervous system; gut; male reproductive gland or organ; and respiratory system. Orthologous to human MATCAP2 (microtubule associated tyrosine carboxypeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 8.7), CNS E18 (RPKM 1.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Matcap2 in Genome Data Viewer
Location:
9 A3; 9 9.14 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22299849..22355980)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22388559..22444684)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23543 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23549 Neighboring gene anillin, actin binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2286 Neighboring gene STARR-seq mESC enhancer starr_23553 Neighboring gene STARR-seq mESC enhancer starr_23554 Neighboring gene STARR-positive B cell enhancer ABC_E5056 Neighboring gene retinitis pigmentosa 9 (human) Neighboring gene ribosomal protein L7A pseudogene Neighboring gene Bardet-Biedl syndrome 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA0895

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative tyrosine carboxypeptidase MATCAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378982.1 → NP_001365911.1  putative tyrosine carboxypeptidase MATCAP2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform b.
    Source sequence(s)
    AC093926
    Conserved Domains (1) summary
    cl06858
    Location:77 → 418
    DUF1704; Domain of unknown function (DUF1704)

  2. NM_001378983.1 → NP_001365912.1  putative tyrosine carboxypeptidase MATCAP2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AC093926
    Conserved Domains (1) summary
    cl06858
    Location:77 → 418
    DUF1704; Domain of unknown function (DUF1704)

  3. NM_026739.3 → NP_081015.1  putative tyrosine carboxypeptidase MATCAP2 isoform a

    See identical proteins and their annotated locations for NP_081015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC093926
    Consensus CDS
    CCDS40563.1
    UniProtKB/Swiss-Prot
    Q5DU11, Q7TQE7, Q80V66, Q9CTJ2
    Related
    ENSMUSP00000062120.8, ENSMUST00000058868.9
    Conserved Domains (1) summary
    cl06858
    Location:177 → 518
    DUF1704; Domain of unknown function (DUF1704)

RNA

  1. NR_152381.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093926
    Related
    ENSMUST00000213598.2

  2. NR_152382.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093926

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    22299849..22355980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510573.2 → XP_006510636.1  putative tyrosine carboxypeptidase MATCAP2 isoform X5

    See identical proteins and their annotated locations for XP_006510636.1

    UniProtKB/Swiss-Prot
    Q7TQE7
    Conserved Domains (1) summary
    cl06858
    Location:43 → 235
    DUF1704; Domain of unknown function (DUF1704)

  2. XM_036155226.1 → XP_036011119.1  putative tyrosine carboxypeptidase MATCAP2 isoform X4

    Conserved Domains (1) summary
    cl06858
    Location:107 → 299
    DUF1704; Domain of unknown function (DUF1704)

  3. XM_006510568.5 → XP_006510631.2  putative tyrosine carboxypeptidase MATCAP2 isoform X2

    Conserved Domains (1) summary
    cl06858
    Location:313 → 588
    DUF1704; Domain of unknown function (DUF1704)

  4. XM_011242589.3 → XP_011240891.2  putative tyrosine carboxypeptidase MATCAP2 isoform X3

    Conserved Domains (1) summary
    cl06858
    Location:180 → 455
    DUF1704; Domain of unknown function (DUF1704)

  5. XM_036155225.1 → XP_036011118.1  putative tyrosine carboxypeptidase MATCAP2 isoform X1

    Conserved Domains (1) summary
    cl06858
    Location:325 → 513
    DUF1704; Domain of unknown function (DUF1704)

  6. XM_011242592.2 → XP_011240894.1  putative tyrosine carboxypeptidase MATCAP2 isoform X5

    See identical proteins and their annotated locations for XP_011240894.1

    UniProtKB/Swiss-Prot
    Q7TQE7
    Related
    ENSMUST00000213133.2
    Conserved Domains (1) summary
    cl06858
    Location:43 → 235
    DUF1704; Domain of unknown function (DUF1704)

  7. XM_017313548.1 → XP_017169037.1  putative tyrosine carboxypeptidase MATCAP2 isoform X5

    UniProtKB/Swiss-Prot
    Q7TQE7
    Conserved Domains (1) summary
    cl06858
    Location:43 → 235
    DUF1704; Domain of unknown function (DUF1704)

RNA

  1. XR_004935540.1 RNA Sequence

  2. XR_001779003.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183273.1: Suppressed sequence

    Description
    NM_183273.1: This RefSeq has been removed because currently there is not sufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQE7.2 GenPept UniProtKB/Swiss-Prot:Q7TQE7

Gene LinkOut

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