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SULT1A3 sulfotransferase family 1A member 3 [ Homo sapiens (human) ]

Gene ID: 6818, updated on 7-Apr-2024

Summary

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Official Symbol
SULT1A3provided by HGNC
Official Full Name
sulfotransferase family 1A member 3provided by HGNC
Primary source
HGNC:HGNC:11455
See related
Ensembl:ENSG00000261052 MIM:600641; AllianceGenome:HGNC:11455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STM; HAST; HAST3; M-PST; ST1A3; ST1A4; ST1A5; TL-PST; ST1A3/ST1A4
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Expression
Broad expression in duodenum (RPKM 134.6), small intestine (RPKM 93.8) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30199255..30204310)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30483809..30488863)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30210576..30215631)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:30204716-30205440 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30206166-30206889 Neighboring gene bolA family member 2B Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit Neighboring gene SAGA complex associated factor 29 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30218380-30219378 Neighboring gene uncharacterized LOC101929894 Neighboring gene phospholipase A2 group XJ, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma. Zou J, et al. Tumour Biol, 2017 Oct. PMID 29025375
  2. Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation. Cook I, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630292, Free PMC Article
  3. Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease. Butcher NJ, et al. Pharmacogenomics J, 2018 Apr. PMID 28374858
  4. Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan. Yamamoto A, et al. Biol Pharm Bull, 2016. PMID 27582324
  5. Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Hui Y, et al. Eur J Pharmacol, 2015 Aug 15. PMID 25941087, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
    Title: Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
  2. Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.
    Title: Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.
  3. Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
    Title: Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
  4. The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
    Title: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.
  5. In Alzheimer's disease patients, there was a significantly lower copy number in SULT1A3 genes compared to controls.
    Title: Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.
  6. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
    Title: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.
  7. analysis of the catechin-binding site of SULT1A3
    Title: Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.
  8. Our results implied that SULT1A3/4 exhibited bidirectional effect on tumor and normal hepatocytes and may thus provide a novel strategy for hepatocellular carcinoma clinical targeting. In addition, SULT1A3/4 re-expression could serve as a biomarker for hepatocellular carcinoma prognosis.
    Title: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
  9. The present study revealed SULT1A3 as the major human SULT enzyme capable of sulfating dextrorphan
    Title: Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan.
  10. Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.
    Title: Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough SLX1A-SULT1A3

Readthrough gene: SLX1A-SULT1A3, Included gene: SLX1A

Homology

Clone Names

  • MGC117469

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amine sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to dopamine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ethanol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in flavonoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sulfotransferase 1A3
Names
Sulfotransferase 1A4
aryl sulfotransferase 1A3/1A4
catecholamine-sulfating phenol sulfotransferase
dopamine-specific sulfotransferase
monoamine-sulfating phenosulfotransferase
phenol sulfotransferase 1A5
placental estrogen sulfotransferase
sulfokinase
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
thermolabile (monoamine, M form) phenol sulfotransferase
NP_808220.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177552.4 → NP_808220.1  sulfotransferase 1A3

    See identical proteins and their annotated locations for NP_808220.1

    Status: REVIEWED

    Source sequence(s)
    BC078144, BC144355
    Consensus CDS
    CCDS10674.1
    UniProtKB/Swiss-Prot
    B4DNV0, O95603, P0DMM9, P0DMN0, P50224, Q1ET66, Q6ZWJ5
    UniProtKB/TrEMBL
    B3KT14, Q1ET61, Q1ET62, Q1ET63, Q2TAB3
    Related
    ENSP00000343645.6, ENST00000338971.10
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30199255..30204310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30483809..30488863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017387.1: Suppressed sequence

    Description
    NM_001017387.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  2. NM_003166.3: Suppressed sequence

    Description
    NM_003166.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMM9.1 GenPept UniProtKB/Swiss-Prot:P0DMM9

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous