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STYX serine/threonine/tyrosine interacting protein [ Homo sapiens (human) ]

Gene ID: 6815, updated on 11-Apr-2024

Summary

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Official Symbol
STYXprovided by HGNC
Official Full Name
serine/threonine/tyrosine interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:11447
See related
Ensembl:ENSG00000198252 MIM:615814; AllianceGenome:HGNC:11447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
14q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (52730166..52774989)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (46937959..46982783)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53196884..53241707)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:53130319-53130927 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:53161801-53162302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5748 Neighboring gene Sharpr-MPRA regulatory region 400 Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:53218646-53218797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8397 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr14:53257919-53258432 and GRCh37_chr14:53258433-53258947 Neighboring gene uncharacterized LOC105370500 Neighboring gene glucosamine-phosphate N-acetyltransferase 1 Neighboring gene COP9 signalosome subunit 9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STYX: a versatile pseudophosphatase. Reiterer V, et al. Biochem Soc Trans, 2017 Apr 15. PMID 28408485
  2. STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch-mTOR signaling pathway. Liu L, et al. Biosci Rep, 2020 Apr 30. PMID 32239181, Free PMC Article
  3. Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer. He D, et al. Cancer Lett, 2019 Jul 10. PMID 30981757
  4. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. Wishart MJ, et al. J Biol Chem, 1995 Nov 10. PMID 7592916
  5. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. Dayton MA, et al. Recept Signal Transduct, 1997. PMID 9633825

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch-mTOR signaling pathway.
    Title: STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch-mTOR signaling pathway.
  2. STYX bound to the F-box and WD repeat domain-containing7 (FBXW7) protein and inhibited its function. Co-regulation of STYX and FBXW7 expression reversed the biological changes mediated by regulation of STYX expression alone in CRC cells.
    Title: Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer.
  3. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex.
    Title: The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
  4. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review]
    Title: STYX: a versatile pseudophosphatase.
  5. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration
    Title: Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Identification of potentially damaging amino acid substitutions leading to human male infertility.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables F-box domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables F-box domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables pseudophosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine/tyrosine-interacting protein
Names
inactive tyrosine-protein phosphatase STYX
phosphoserine/threonine/tyrosine interaction protein
protein tyrosine phosphatase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030377.1 RefSeqGene

    Range
    5002..49825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130701.2 → NP_001124173.1  serine/threonine/tyrosine-interacting protein

    See identical proteins and their annotated locations for NP_001124173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses different splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL139317, AL832591, BQ772275, DB498442
    Consensus CDS
    CCDS9711.1
    UniProtKB/Swiss-Prot
    B9EJG0, Q8WUJ0, Q99850
    Related
    ENSP00000403214.2, ENST00000442123.6
    Conserved Domains (1) summary
    cd14522
    Location:25 → 175
    DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

  2. NM_145251.4 → NP_660294.1  serine/threonine/tyrosine-interacting protein

    See identical proteins and their annotated locations for NP_660294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK098195, AL139317, BC020265, BQ772275, DB498442
    Consensus CDS
    CCDS9711.1
    UniProtKB/Swiss-Prot
    B9EJG0, Q8WUJ0, Q99850
    Related
    ENSP00000346599.4, ENST00000354586.5
    Conserved Domains (1) summary
    cd14522
    Location:25 → 175
    DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    52730166..52774989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537108.2 → XP_011535410.1  serine/threonine/tyrosine-interacting protein isoform X1

    Conserved Domains (1) summary
    cd00127
    Location:4 → 147
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  2. XM_047431731.1 → XP_047287687.1  serine/threonine/tyrosine-interacting protein isoform X2

  3. XM_011537109.3 → XP_011535411.1  serine/threonine/tyrosine-interacting protein isoform X3

    Conserved Domains (1) summary
    cl21483
    Location:2 → 60
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    46937959..46982783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376650.1 → XP_054232625.1  serine/threonine/tyrosine-interacting protein isoform X1

  2. XM_054376651.1 → XP_054232626.1  serine/threonine/tyrosine-interacting protein isoform X2

  3. XM_054376652.1 → XP_054232627.1  serine/threonine/tyrosine-interacting protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUJ0.1 GenPept UniProtKB/Swiss-Prot:Q8WUJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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